Literature DB >> 11906812

Beyond Mitomycin: TGF-beta and wound healing.

M Francesca Cordeiro1.   

Abstract

The introduction of the anti-cancer drugs Mitomycin and 5-fluorouracil as anti-scarring agents within the last decade, has greatly improved surgical results of glaucoma filtration surgery. However, a number of problems associated with their use have emerged. At the same time, the transforming growth factor-beta (TGF-beta) has been identified as an important component of wound healing, particularly in the conjunctival scarring response. Recent developments in molecular therapy offer exciting prospects for the modulation of wound healing, specifically those targeting TGF-beta. As TGF-beta is such a potent stimulant of scarring, this review examines its biology and role in ocular wound healing and repair, and discusses promising new approaches to modifying its activity.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11906812     DOI： 10.1016/s1350-9462(01)00021-0

Source DB:  PubMed          Journal:  Prog Retin Eye Res        ISSN： 1350-9462            Impact factor:   21.198


  12 in total

Review 1.  Role of transforming growth factor Beta in corneal function, biology and pathology.

Authors:  A Tandon; J C K Tovey; A Sharma; R Gupta; R R Mohan
Journal:  Curr Mol Med       Date:  2010-08       Impact factor: 2.222

2.  Experimental manipulation of transforming growth factor-beta isoforms significantly affects adhesion formation in a murine surgical model.

Authors:  Dylan A Gorvy; Sarah E Herrick; Mamta Shah; Mark W J Ferguson
Journal:  Am J Pathol       Date:  2005-10       Impact factor: 4.307

3.  Fibrosis of pulmonary vascular remodeling in carotid artery-jugular vein shunt pulmonary artery hypertension model of rats.

Authors:  Mai Xiong; Jian-Ping Yao; Zhong-Kai Wu; Bing Liao; Ying-Jie Liang; Xi Zhang; Zhi-Ping Wang
Journal:  Eur J Cardiothorac Surg       Date:  2012-01       Impact factor: 4.191

4.  Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix.

Authors:  Li Guo; Stephen E Moss; Robert A Alexander; Robin R Ali; Frederick W Fitzke; M Francesca Cordeiro
Journal:  Invest Ophthalmol Vis Sci       Date:  2005-01       Impact factor: 4.799

5.  A sequential, multiple-treatment, targeted approach to reduce wound healing and failure of glaucoma filtration surgery in a rabbit model (an American Ophthalmological Society thesis).

Authors:  Mark Brian Sherwood
Journal:  Trans Am Ophthalmol Soc       Date:  2006

6.  Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor.

Authors:  Jennifer Sapitro; Jeffrey J Dunmire; Sarah E Scott; Vijay Sutariya; Werner J Geldenhuys; Michael Hewit; Beatrice Y J T Yue; Hiroshi Nakamura
Journal:  Mol Vis       Date:  2010-09-16       Impact factor: 2.367

7.  Combining use of captopril and losartan attenuates the progress of Streptococcus pneumoniae-induced tympanosclerosis through the suppression of TGF-β1 expression.

Authors:  Wenqing Yan; Jianfeng Li; Renjie Chai; Wentao Guo; Lei Xu; Yuechen Han; Xiaohui Bai; Haibo Wang
Journal:  PLoS One       Date:  2014-10-31       Impact factor: 3.240

Review 8.  Current concepts in the pathophysiology of glaucoma.

Authors:  Renu Agarwal; Suresh K Gupta; Puneet Agarwal; Rohit Saxena; Shyam S Agrawal
Journal:  Indian J Ophthalmol       Date:  2009 Jul-Aug       Impact factor: 1.848

9.  Downregulation of LIM kinase 1 suppresses ocular inflammation and fibrosis.

Authors:  Matvey Gorovoy; Takahisa Koga; Xiang Shen; Zhengping Jia; Beatrice Y Yue; Tatyana Voyno-Yasenetskaya
Journal:  Mol Vis       Date:  2008-10-30       Impact factor: 2.367

10.  The CLC-2 Chloride Channel Modulates ECM Synthesis, Differentiation, and Migration of Human Conjunctival Fibroblasts via the PI3K/Akt Signaling Pathway.

Authors:  Lixia Sun; Yaru Dong; Jing Zhao; Yuan Yin; Yajuan Zheng
Journal:  Int J Mol Sci       Date:  2016-06-09       Impact factor: 5.923
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.