Literature DB >> 11906205

TGFbeta1 modulates the phenotype of Schwann cells at the transcriptional level.

Rajeshwar Awatramani1, Susan Shumas, John Kamholz, Steven S Scherer.   

Abstract

We have examined the effects of transforming growth factor beta1 (TGFbeta1) on gene expression in cultured rat Schwann cells (SCs). TGFbeta1 decreased the steady-state mRNA levels of several genes that are expressed by myelinating SCs but had varied effects on the mRNA levels of NCAM, L1, GAP-43, and p75-genes that are expressed by denervated and nonmyelinating SCs. TGFbeta1 antagonized the effects of forskolin on the mRNA levels of the transcription factors Oct-6/tst-1/SCIP and Krox20. Transcriptional run-off analysis demonstrated that the effects of TGFbeta1 on gene expression occur at least in part at the level of transcription. Thus, TGFbeta1 suppresses the expression of genes that characterize the different phenotypes of SCs, and these changes occur at least in part at a transcriptional level.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11906205     DOI： 10.1006/mcne.2001.1094

Source DB:  PubMed          Journal:  Mol Cell Neurosci        ISSN： 1044-7431            Impact factor:   4.314


  10 in total

1.  Developmental regulation of microRNA expression in Schwann cells.

Authors:  Nolan G Gokey; Rajini Srinivasan; Camila Lopez-Anido; Courtney Krueger; John Svaren
Journal:  Mol Cell Biol       Date:  2011-11-07       Impact factor: 4.272

2.  Satellite glial cell proliferation in the trigeminal ganglia after chronic constriction injury of the infraorbital nerve.

Authors:  Macayla Donegan; Melanie Kernisant; Criselda Cua; Luc Jasmin; Peter T Ohara
Journal:  Glia       Date:  2013-10-03       Impact factor: 7.452

Review 3.  To build a synapse: signaling pathways in neuromuscular junction assembly.

Authors:  Haitao Wu; Wen C Xiong; Lin Mei
Journal:  Development       Date:  2010-04       Impact factor: 6.868

4.  MONaKA, a novel modulator of the plasma membrane Na,K-ATPase.

Authors:  Hua Mao; Tanya S Ferguson; Susan M Cibulsky; Mats Holmqvist; Chunming Ding; Hong Fei; Irwin B Levitan
Journal:  J Neurosci       Date:  2005-08-31       Impact factor: 6.167

5.  Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination.

Authors:  Nam Le; Rakesh Nagarajan; James Y T Wang; Toshiyuki Araki; Robert E Schmidt; Jeffrey Milbrandt
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-03       Impact factor: 11.205

Review 6.  Role of Transforming Growth Factor Beta in Peripheral Nerve Regeneration: Cellular and Molecular Mechanisms.

Authors:  Zhiqian Ye; Junbin Wei; Chaoning Zhan; Jin Hou
Journal:  Front Neurosci       Date:  2022-06-13       Impact factor: 5.152

7.  ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury.

Authors:  Suzana Atanasoski; Steven S Scherer; Erich Sirkowski; Dino Leone; Alistair N Garratt; Carmen Birchmeier; Ueli Suter
Journal:  J Neurosci       Date:  2006-02-15       Impact factor: 6.167

8.  TGFbeta type II receptor signaling controls Schwann cell death and proliferation in developing nerves.

Authors:  Maurizio D'Antonio; Anna Droggiti; M Laura Feltri; Jürgen Roes; Lawrence Wrabetz; Rhona Mirsky; Kristján R Jessen
Journal:  J Neurosci       Date:  2006-08-16       Impact factor: 6.167

9.  The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin.

Authors:  Frank L Rice; George Houk; James P Wymer; Sara J C Gosline; Justin Guinney; Jianqiang Wu; Nancy Ratner; Michael P Jankowski; Salvo La Rosa; Marilyn Dockum; James R Storey; Steven L Carroll; Phillip J Albrecht; Vincent M Riccardi
Journal:  PLoS One       Date:  2019-05-20       Impact factor: 3.752

10.  Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death.

Authors:  David B Parkinson; Ambily Bhaskaran; Anna Droggiti; Sarah Dickinson; Maurizio D'Antonio; Rhona Mirsky; Kristjan R Jessen
Journal:  J Cell Biol       Date:  2004-02-02       Impact factor: 10.539
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.