Literature DB >> 11905834

Transgenic analysis of thymocyte signal transduction.

Doreen A Cantrell1.   

Abstract

This review examines the value of transgenic studies in mice for the genetic dissection of signal-transduction pathways relevant to thymus development. T-cell development in the thymus is controlled by an ordered sequence of differentiation and proliferation checkpoints that culminate in the production of correctly selected, non-autoreactive, peripheral T lymphocytes. Work in transgenic mice has been fundamental for the preparation of genetic maps of signal-transduction pathways that control T-cell development. This review discusses how tyrosine kinases, guanine-nucleotide-binding proteins and transcription factors converge to control T-cell differentiation and proliferation in the immune system.

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Year:  2002        PMID： 11905834     DOI： 10.1038/nri703

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  22 in total

1.  Essential role of TAK1 in thymocyte development and activation.

Authors:  Hong-Hsing Liu; Min Xie; Michael D Schneider; Zhijian J Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-20       Impact factor: 11.205

2.  Miro's N-terminal GTPase domain is required for transport of mitochondria into axons and dendrites.

Authors:  Milos Babic; Gary J Russo; Andrea J Wellington; Ryan M Sangston; Migdalia Gonzalez; Konrad E Zinsmaier
Journal:  J Neurosci       Date:  2015-04-08       Impact factor: 6.167

3.  Role for Ets-2(Thr-72) transcription factor in stage-specific thymocyte development and survival.

Authors:  Ian B Fisher; Mike Ostrowski; Natarajan Muthusamy
Journal:  J Biol Chem       Date:  2011-11-29       Impact factor: 5.157

4.  Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.

Authors:  Gregory F Wu; Evann Corbo; Michelle Schmidt; Jennifer E Smith-Garvin; Matthew J Riese; Martha S Jordan; Terri M Laufer; Eric J Brown; Jonathan S Maltzman
Journal:  Eur J Immunol       Date:  2011-06-07       Impact factor: 5.532

Review 5.  Abl tyrosine kinases in T-cell signaling.

Authors:  Jing Jin Gu; Jae Ryun Ryu; Ann Marie Pendergast
Journal:  Immunol Rev       Date:  2009-03       Impact factor: 12.988

6.  ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.

Authors:  Allison J Armstrong; Abraham K Gebre; John S Parks; Catherine C Hedrick
Journal:  J Immunol       Date:  2009-11-30       Impact factor: 5.422

7.  Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.

Authors:  Xuefeng Wu; Masahiro Yamamoto; Shizuo Akira; Shao-Cong Sun
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-19       Impact factor: 11.205

8.  Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis.

Authors:  Rene Opavsky; Shih-Yin Tsai; Martin Guimond; Anjulie Arora; Jana Opavska; Brian Becknell; Michael Kaufmann; Nathaniel A Walton; Julie A Stephens; Soledad A Fernandez; Natarajan Muthusamy; Dean W Felsher; Pierluigi Porcu; Michael A Caligiuri; Gustavo Leone
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-19       Impact factor: 11.205

9.  Characterization of thymocyte phenotypic alterations induced by long-lasting beta-adrenoceptor blockade in vivo and its effects on thymocyte proliferation and apoptosis.

Authors:  G Leposavić; N Arsenović-Ranin; K Radojević; D Kosec; V Pesić; B Vidić-Danković; B Plećas-Solarović; I Pilipović
Journal:  Mol Cell Biochem       Date:  2006-02-14       Impact factor: 3.396

10.  LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells.

Authors:  Peter Tamás; Andrew Macintyre; David Finlay; Rosemary Clarke; Carmen Feijoo-Carnero; Alan Ashworth; Doreen Cantrell
Journal:  Eur J Immunol       Date:  2010-01       Impact factor: 5.532
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