Literature DB >> 11902644

Antimicrobial activity of 5-arylidene aromatic derivatives of hydantoin. Part 2.

Ewa Szymańska1, Katarzyna Kieć-Kononowicz, Anna Białecka, Andrzej Kasprowicz.   

Abstract

Various 5-chloroarylidene-2-amino substituted derivatives of imidazoline-4-one were synthesized and evaluated for their activity in vitro against Mycobacterium tuberculosis and other type strains of bacteria and fungi. 2-Chloro- and 2,4-dichlorobenzylidene substituted hydantoins exhibited antimycobacterial effect. The most potent compounds 3i, 3j, 3o, 3q and 3s were classified for further tests. The antimitotic effect of the investigated hydantoins was also examined.

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Year:  2002        PMID： 11902644     DOI： 10.1016/s0014-827x(01)01172-7

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  5 in total

1.  Reactivity of 2-thiohydantoins towards various electrophilic reagents: applications to the synthesis of new 2-ylidene-3,5-dihydro-4H-imidazol-4-ones.

Authors:  Jean-René Chérouvrier; François Carreaux; Jean Pierre Bazureau
Journal:  Molecules       Date:  2004-09-30       Impact factor: 4.411

2.  Membrane-Active Hydantoin Derivatives as Antibiotic Agents.

Authors:  Ma Su; Donglin Xia; Peng Teng; Alekhya Nimmagadda; Chao Zhang; Timothy Odom; Annie Cao; Yong Hu; Jianfeng Cai
Journal:  J Med Chem       Date:  2017-10-06       Impact factor: 7.446

3.  Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay.

Authors:  Jürgen A Bohnert; Sabine Schuster; Winfried V Kern; Tadeusz Karcz; Agnieszka Olejarz; Aneta Kaczor; Jadwiga Handzlik; Katarzyna Kieć-Kononowicz
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

4.  Development of Bis-cyclic Imidazolidine-4-one Derivatives as Potent Antibacterial Agents.

Authors:  Minghui Wang; Ruixuan Gao; Mengmeng Zheng; Peng Sang; Chunpu Li; En Zhang; Qi Li; Jianfeng Cai
Journal:  J Med Chem       Date:  2020-09-24       Impact factor: 7.446

5.  Facile synthesis of 5-arylidene thiohydantoin by sequential sulfonylation/desulfination reaction.

Authors:  Jintao Han; Hongbo Dong; Zhihong Xu; Jianping Lei; Mingan Wang
Journal:  Int J Mol Sci       Date:  2013-06-13       Impact factor: 5.923
  5 in total

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