Literature DB >> 11901813

Human tissue kallikrein gene family: a rich source of novel disease biomarkers.

E P Diamandis1, G M Yousef.   

Abstract

The organization of the human tissue kallikrein gene family has now been fully elucidated. This family contains 15 genes encoding secreted serine proteases, which share significant homologies at both the DNA and amino acid level. Two members of the human kallikrein gene family, prostate-specific antigen and human kallikrein 2, have already found important clinical application as prostate cancer biomarkers. In this review, we examine the diagnostic and prognostic value of the 15 human kallikrein genes and proteins. It is clear that at least a few members show promise of becoming novel cancer and other disease biomarkers.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11901813     DOI： 10.1586/14737159.1.2.182

Source DB:  PubMed          Journal:  Expert Rev Mol Diagn        ISSN： 1473-7159            Impact factor:   5.225


  15 in total

1.  Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases.

Authors:  Hyesook Yoon; Sachiko I Blaber; Wu Li; Isobel A Scarisbrick; Michael Blaber
Journal:  Biol Chem       Date:  2013-01       Impact factor: 3.915

2.  Human kallikrein 8 expression in salivary gland tumors.

Authors:  Mark R Darling; Sam Tsai; Linda Jackson-Boeters; Thomas D Daley; Eleftherios P Diamandis
Journal:  Head Neck Pathol       Date:  2008-07-03

Review 3.  Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis.

Authors:  Michael Blaber; Hyesook Yoon; Maria A Juliano; Isobel A Scarisbrick; Sachiko I Blaber
Journal:  Biol Chem       Date:  2010-04       Impact factor: 3.915

4.  Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis.

Authors:  Hyesook Yoon; Sachiko I Blaber; D Michael Evans; Julie Trim; Maria Aparecida Juliano; Isobel A Scarisbrick; Michael Blaber
Journal:  Protein Sci       Date:  2008-08-12       Impact factor: 6.725

5.  A completed KLK activome profile: investigation of activation profiles of KLK9, 10, and 15.

Authors:  Hyesook Yoon; Sachiko I Blaber; Mekdes Debela; Peter Goettig; Isobel A Scarisbrick; Michael Blaber
Journal:  Biol Chem       Date:  2009-04       Impact factor: 3.915

Review 6.  Emerging PSA-based tests to improve screening.

Authors:  Richard J Bryant; Hans Lilja
Journal:  Urol Clin North Am       Date:  2014-02-26       Impact factor: 2.241

7.  Association of TMPRSS2 and KLK11 gene expression levels with clinical progression of human prostate cancer.

Authors:  Xuecheng Bi; Huichan He; Yongkang Ye; Qishan Dai; Zhaodong Han; Yunxiang Liang; Weide Zhong
Journal:  Med Oncol       Date:  2009-02-26       Impact factor: 3.064

8.  A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival.

Authors:  Jyotsna Batra; Christina M Nagle; Tracy O'Mara; Melanie Higgins; Ying Dong; Olivia L Tan; Felicity Lose; Lene Marie Skeie; Srilakshmi Srinivasan; Kelly L Bolton; Honglin Song; Susan J Ramus; Simon A Gayther; Paul D P Pharoah; Mary-Anne Kedda; Amanda B Spurdle; Judith A Clements
Journal:  BMC Cancer       Date:  2011-04-01       Impact factor: 4.430

9.  The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer.

Authors:  G M Yousef; A Scorilas; A Magklara; N Memari; R Ponzone; P Sismondi; N Biglia; M Abd Ellatif; E P Diamandis
Journal:  Br J Cancer       Date:  2002-11-18       Impact factor: 7.640

10.  Vaspin inhibits kallikrein 7 by serpin mechanism.

Authors:  John T Heiker; Nora Klöting; Peter Kovacs; E Bartholomeus Kuettner; Norbert Sträter; Stephan Schultz; Matthias Kern; Michael Stumvoll; Matthias Blüher; Annette G Beck-Sickinger
Journal:  Cell Mol Life Sci       Date:  2013-01-31       Impact factor: 9.261
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.