BACKGROUND:Long-term ventricular resynchronization therapy improves symptom status. Changes in left ventricular remodeling have not been adequately evaluated. METHODS AND RESULTS: Fifty-three patients with systolic heart failure and bundle-branch block underwent implantation of biventricular stimulation (BVS) devices as part of a randomized trial. Echocardiograms were acquired at randomization and at 6-week intervals until completion of 12 weeks of continuous BVS. There were no changes in heart rate or QRS duration after 12 weeks of BVS. Serum norepinephrine values did not change with BVS. After 12 weeks of BVS, left atrial volume decreased. Left ventricular end-systolic and end-diastolic dimensions and left ventricular end-systolic volume also decreased after 12 weeks of BVS. Sphericity index did not change. Measures of systolic function, including left ventricular outflow tract and aortic velocity time integral and myocardial performance index, improved. CONCLUSIONS: Long-term resynchronization therapy results in atrial and ventricular reverse remodeling and improved hemodynamics.
RCT Entities:
BACKGROUND: Long-term ventricular resynchronization therapy improves symptom status. Changes in left ventricular remodeling have not been adequately evaluated. METHODS AND RESULTS: Fifty-three patients with systolic heart failure and bundle-branch block underwent implantation of biventricular stimulation (BVS) devices as part of a randomized trial. Echocardiograms were acquired at randomization and at 6-week intervals until completion of 12 weeks of continuous BVS. There were no changes in heart rate or QRS duration after 12 weeks of BVS. Serum norepinephrine values did not change with BVS. After 12 weeks of BVS, left atrial volume decreased. Left ventricular end-systolic and end-diastolic dimensions and left ventricular end-systolic volume also decreased after 12 weeks of BVS. Sphericity index did not change. Measures of systolic function, including left ventricular outflow tract and aortic velocity time integral and myocardial performance index, improved. CONCLUSIONS: Long-term resynchronization therapy results in atrial and ventricular reverse remodeling and improved hemodynamics.
Authors: José M Dizon; T Alexander Quinn; Santos E Cabreriza; Daniel Wang; Henry M Spotnitz; Kathleen Hickey; Hasan Garan Journal: Europace Date: 2010-06-04 Impact factor: 5.214
Authors: Aiden Abidov; Piotr J Slomka; Hidetaka Nishina; Sean W Hayes; Xingping Kang; Shunichi Yoda; Ling-De Yang; James Gerlach; Fatma Aboul-Enein; Ishac Cohen; John D Friedman; Paul B Kavanagh; Guido Germano; Daniel S Berman Journal: J Nucl Cardiol Date: 2006-09 Impact factor: 5.952
Authors: Gregory W Woo; Susan Petersen-Stejskal; James W Johnson; Jamie B Conti; Juan A Aranda; Anne B Curtis Journal: J Interv Card Electrophysiol Date: 2005-03 Impact factor: 1.900