Cellular and molecular basis for the formation of lamina-specific thalamocortical projections.

The neocortex is composed of a characteristic layered structure, which is a basis of extrinsic and intrinsic cortical connections. In recent years the cellular and molecular mechanisms, which are responsible for the formation of lamina-specific connections, have been explored by extensive molecular and in vitro studies. This article attempts to address what cell-cell interactions are required for axonal targeting and what molecules regulate cellular events, focusing upon the development of the thalamocortical projection.