OBJECTIVE: While chewing areca nut is considered a risk factor for oral submucous fibrosis, the effects of cigarette smoking, alcohol drinking, and body mass index (BMI) have not been examined; nor are they well established. In this study we investigated the association between BMI, smoking, drinking, and the risk of oral submucous fibrosis. METHODS: We conducted a case-control study within the framework of an ongoing randomized oral cancer screening trial in Kerala, India. Trained health workers conducted interviews with structured questionnaires and oral visual inspections to diagnose oral premalignant lesions. A total of 170 oral submucous fibrosis cases (139 women and 31 men) and 47,773 controls were identified. The odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression in SAS. RESULTS: The adjusted OR for ever-tobacco chewing was 44.1 (95% CI = 22.0-88.2). An inverse dose-response relationship was seen between BMI and the risk of oral submucous fibrosis when both genders were combined (p for trend = 0.0010), with an OR of 0.5 (95% CI = 0.3-0.9) for the highest BMI quartile compared to the lowest. Alcohol drinking may possibly be associated with the risk of oral submucous fibrosis; the adjusted OR for ever drinking was 2.1 (95% CI = 1.0-4.4). Cigarette smoking did not appear to be a risk factor for women or for men. Both smoking and drinking were rare habits among women. CONCLUSION: This study suggested, for the first time, that BMI was inversely associated with the risk of oral submucous fibrosis for both genders when potential confounding factors were adjusted. Our results indicated that alcohol drinking might be a moderate risk factor and confirmed the previous observation that chewing tobacco was a strong risk factor for oral submucous fibrosis.
OBJECTIVE: While chewing areca nut is considered a risk factor for oral submucous fibrosis, the effects of cigarette smoking, alcohol drinking, and body mass index (BMI) have not been examined; nor are they well established. In this study we investigated the association between BMI, smoking, drinking, and the risk of oral submucous fibrosis. METHODS: We conducted a case-control study within the framework of an ongoing randomized oral cancer screening trial in Kerala, India. Trained health workers conducted interviews with structured questionnaires and oral visual inspections to diagnose oral premalignant lesions. A total of 170 oral submucous fibrosis cases (139 women and 31 men) and 47,773 controls were identified. The odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression in SAS. RESULTS: The adjusted OR for ever-tobacco chewing was 44.1 (95% CI = 22.0-88.2). An inverse dose-response relationship was seen between BMI and the risk of oral submucous fibrosis when both genders were combined (p for trend = 0.0010), with an OR of 0.5 (95% CI = 0.3-0.9) for the highest BMI quartile compared to the lowest. Alcohol drinking may possibly be associated with the risk of oral submucous fibrosis; the adjusted OR for ever drinking was 2.1 (95% CI = 1.0-4.4). Cigarette smoking did not appear to be a risk factor for women or for men. Both smoking and drinking were rare habits among women. CONCLUSION: This study suggested, for the first time, that BMI was inversely associated with the risk of oral submucous fibrosis for both genders when potential confounding factors were adjusted. Our results indicated that alcohol drinking might be a moderate risk factor and confirmed the previous observation that chewing tobacco was a strong risk factor for oral submucous fibrosis.
Authors: Jay H Lubin; Joshua Muscat; Mia M Gaudet; Andrew F Olshan; Maria Paula Curado; Luigino Dal Maso; Victor Wünsch-Filho; Erich M Sturgis; Neonilia Szeszenia-Dabrowska; Xavier Castellsague; Zuo-Feng Zhang; Elaine Smith; Leticia Fernandez; Elena Matos; Silvia Franceschi; Eleonora Fabianova; Peter Rudnai; Mark P Purdue; Dana Mates; Qingyi Wei; Rolando Herrero; Karl Kelsey; Hal Morgenstern; Oxana Shangina; Sergio Koifman; Jolanta Lissowska; Fabio Levi; Alexander W Daudt; Jose Eluf Neto; Chu Chen; Philip Lazarus; Deborah M Winn; Stephen M Schwartz; Paolo Boffetta; Paul Brennan; Ana Menezes; Carlo La Vecchia; Michael McClean; Renato Talamini; Thangarajan Rajkumar; Richard B Hayes; Mia Hashibe Journal: Cancer Causes Control Date: 2011-07-09 Impact factor: 2.506
Authors: Jay H Lubin; Mia M Gaudet; Andrew F Olshan; Karl Kelsey; Paolo Boffetta; Paul Brennan; Xavier Castellsague; Chu Chen; Maria Paula Curado; Luigino Dal Maso; Alexander W Daudt; Eleonora Fabianova; Leticia Fernandez; Victor Wünsch-Filho; Silvia Franceschi; Rolando Herrero; Sergio Koifman; Carlo La Vecchia; Philip Lazarus; Fabio Levi; Jolanta Lissowska; Ioan Nicolae Mates; Elena Matos; Michael McClean; Ana Menezes; Hal Morgenstern; Joshua Muscat; Jose Eluf Neto; Mark P Purdue; Peter Rudnai; Stephen M Schwartz; Oxana Shangina; Erich M Sturgis; Neonilia Szeszenia-Dabrowska; Renato Talamini; Qingyi Wei; Deborah Winn; Zuo-Feng Zhang; Mia Hashibe; Richard B Hayes Journal: Am J Epidemiol Date: 2010-05-21 Impact factor: 4.897
Authors: Mia M Gaudet; Andrew F Olshan; Shu-Chun Chuang; Julien Berthiller; Zuo-Feng Zhang; Jolanta Lissowska; David Zaridze; Deborah M Winn; Qingyi Wei; Renato Talamini; Neolilia Szeszenia-Dabrowska; Erich M Sturgis; Stephen M Schwartz; Peter Rudnai; Jose Eluf-Neto; Joshua Muscat; Hal Morgenstern; Ana Menezes; Elena Matos; Alexandru Bucur; Fabio Levi; Philip Lazarus; Carlo La Vecchia; Sergio Koifman; Karl Kelsey; Rolando Herrero; Richard B Hayes; Silva Franceschi; Victor Wunsch-Filho; Leticia Fernandez; Eleonora Fabianova; Alexander W Daudt; Luigino Dal Maso; Maria Paula Curado; Chu Chen; Xavier Castellsague; Simone Benhamou; Paolo Boffetta; Paul Brennan; Mia Hashibe Journal: Int J Epidemiol Date: 2010-02-01 Impact factor: 7.196
Authors: Jessica L Petrick; Mia M Gaudet; Mark C Weissler; William K Funkhouser; Andrew F Olshan Journal: Ann Epidemiol Date: 2013-11-16 Impact factor: 3.797