Literature DB >> 11898548

Epilepsy in the elderly.

I E Leppik1.   

Abstract

The active prevalence rate of epilepsy among persons over 65 years of age is approximately 1.5%, about twice the rate in younger adults. Treatment of epilepsy in the elderly is complicated by alterations in drug metabolism, use of concomitant medications, and multiple medical problems. Drug interactions are a major issue, and a full knowledge of the isoenzyme profile and protein-binding characteristics of each drug (antiepileptic and other) must be known.

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Year:  2001        PMID: 11898548     DOI: 10.1007/s11910-001-0096-5

Source DB:  PubMed          Journal:  Curr Neurol Neurosci Rep        ISSN: 1528-4042            Impact factor:   5.081


  27 in total

1.  The effect of age upon liver volume and apparent liver blood flow in healthy man.

Authors:  H A Wynne; L H Cope; E Mutch; M D Rawlins; K W Woodhouse; O F James
Journal:  Hepatology       Date:  1989-02       Impact factor: 17.425

2.  Phenytoin dosage in the elderly.

Authors:  D C Lambie; F I Caird
Journal:  Age Ageing       Date:  1977-08       Impact factor: 10.668

Review 3.  Drug metabolism in the elderly.

Authors:  B J Cusack
Journal:  J Clin Pharmacol       Date:  1988-06       Impact factor: 3.126

4.  Antiepileptic drugs and alpha 1-acid glycoprotein.

Authors:  E Tiula; P J Neuvonen
Journal:  N Engl J Med       Date:  1982-10-28       Impact factor: 91.245

5.  Pharmacokinetics of valproic acid in the elderly.

Authors:  E Perucca; R Grimaldi; G Gatti; S Pirracchio; F Crema; G M Frigo
Journal:  Br J Clin Pharmacol       Date:  1984-06       Impact factor: 4.335

6.  Decreased phenytoin level during antineoplastic therapy: a case report.

Authors:  P Bollini; R Riva; F Albani; N Ida; L Cacciari; C Bollini; A Baruzzi
Journal:  Epilepsia       Date:  1983-02       Impact factor: 5.864

7.  Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics.

Authors:  J C Cloyd; T E Lackner; I E Leppik
Journal:  Arch Fam Med       Date:  1994-07

8.  Antiepileptic drug use in nursing home residents: effect of age, gender, and comedication on patterns of use.

Authors:  T E Lackner; J C Cloyd; L W Thomas; I E Leppik
Journal:  Epilepsia       Date:  1998-10       Impact factor: 5.864

Review 9.  Seizure activity associated with antipsychotic therapy.

Authors:  J A Cold; B G Wells; J H Froemming
Journal:  DICP       Date:  1990-06

10.  An interaction between cytostatic and anticonvulsant drugs.

Authors:  C Neef; I de Voogd-van der Straaten
Journal:  Clin Pharmacol Ther       Date:  1988-04       Impact factor: 6.875

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