| Literature DB >> 11898403 |
Franz Jakob1, Katja Becker, Ellen Paar, Regina Ebert-Duemig, Norbert Schütze.
Abstract
The expression of thioredoxin reductases and other selenoproteins in cells of the bone microenvironment may represent an important means of regulation of bone resorption and remodeling in health and disease. Selenoproteins and their substrates may influence intracellular and extracellular redox-dependent signaling, transcription factor activity, posttranslational modification of proteins, and general or compartmentalized scavenging from ROIs. However, the evaluation of their biological role in bone and their potential in terms of therapeutic approaches is just beginning.Mesh：
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Year: 2002 PMID： 11898403 DOI： 10.1016/s0076-6879(02)47015-2
Source DB: PubMed Journal: Methods Enzymol ISSN： 0076-6879 Impact factor: 1.600