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Literature DB >> 11897612

Lack of catheter infection by the efg1/efg1 cph1/cph1 double-null mutant, a Candida albicans strain that is defective in filamentous growth.

Russell E Lewis¹, Hsiu-Jung Lo, Issam I Raad, Dimitrios P Kontoyiannis.

Abstract

The molecular controls regulating the successful colonization of Candida albicans on foreign materials are not known. Here we show that a mutant C. albicans strain defective in filamentous growth and lacking the transcription factors Efg1p and Cph1p has a profoundly deficient potential for colonizing on polyurethane catheters.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2002 PMID： 11897612 PMCID： PMC127119 DOI： 10.1128/AAC.46.4.1153-1155.2002

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

9 in total

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Authors: Gordon Ramage; Stephen P Saville; Derek P Thomas; José L López-Ribot
Journal: Eukaryot Cell Date: 2005-04

3. Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicans.

Authors: Yang Lu; Chang Su; Xuming Mao; Prashna Pala Raniga; Haoping Liu; Jiangye Chen
Journal: Mol Biol Cell Date: 2008-08-06 Impact factor: 4.138

Lack of catheter infection by the efg1/efg1 cph1/cph1 double-null mutant, a Candida albicans strain that is defective in filamentous growth.

Review 1. Nosocomial candidiasis: emerging species, reservoirs, and modes of transmission.

Review 2. Signal transduction cascades regulating fungal development and virulence.

3. Nonfilamentous C. albicans mutants are avirulent.

4. Three-year experience with sonicated vascular catheter cultures in a clinical microbiology laboratory.

5. Isogenic strain construction and gene mapping in Candida albicans.

6. Adherence of candida species to intravenous catheters.

7. Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi.

8. Invasive lesions containing filamentous forms produced by a Candida albicans mutant that is defective in filamentous growth in culture.

9. Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog.

1. Genetic control of Candida albicans biofilm development.

Review 2. Candida biofilms: an update.

3. Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicans.

4. Efg1 and Cas5 Orchestrate Cell Wall Damage Response to Caspofungin in Candida albicans.

Review 5. Fungal biofilms, drug resistance, and recurrent infection.

6. Efficacy of zosteric acid sodium salt on the yeast biofilm model Candida albicans.

7. Fungal Biofilms: Relevance in the Setting of Human Disease.

8. Characterization of biofilm formation and the role of BCR1 in clinical isolates of Candida parapsilosis.

9. Fungal Endocarditis.

10. Global screening of potential Candida albicans biofilm-related transcription factors via network comparison.