Literature DB >> 11897599

In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against organisms other than staphylococci.

Junius Clark1, Joan C Fung-Tomc, Beatrice Minassian, Yuan-Hwang Tsai, Hyekyung Yang, Elizabeth Huczko, Benjamin Kolek, Susan Chaniewski, Cheryl Ferraro, Rebecca Drain, Elizabeth Gradelski, Daniel P Bonner.   

Abstract

BMS-247243, a novel cephalosporin inhibitory for methicillin-resistant staphylococci, primarily has activity against gram-positive bacteria. The activities of BMS-247243, cefotaxime, and ceftriaxone against streptococci and Streptococcus pneumoniae were similar. BMS-247243 inhibits Enterococcus faecalis but not Enterococcus faecium. BMS-247243 also inhibits many inherently vancomycin-resistant species (Leuconstoc, Lactobacillus, Pediococcus) and anaerobic gram-positive bacteria.

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Year:  2002        PMID： 11897599      PMCID： PMC127083          DOI： 10.1128/AAC.46.4.1108-1111.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  4 in total

1.  Relatedness between Streptococcus pneumoniae and viridans streptococci: transfer of penicillin resistance determinants and immunological similarities of penicillin-binding proteins.

Authors:  L Chalkley; C Schuster; E Potgieter; R Hakenbeck
Journal:  FEMS Microbiol Lett       Date:  1991-12-15       Impact factor: 2.742

2.  Diffusion of beta-lactam antibiotics through the porin channels of Escherichia coli K-12.

Authors:  F Yoshimura; H Nikaido
Journal:  Antimicrob Agents Chemother       Date:  1985-01       Impact factor: 5.191

3.  In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against methicillin-resistant and -susceptible staphylococci.

Authors:  Joan C Fung-Tomc; Junius Clark; Beatrice Minassian; Michael Pucci; Yuan-Hwang Tsai; Elizabeth Gradelski; Lucinda Lamb; Ivette Medina; Elizabeth Huczko; Benjamin Kolek; Susan Chaniewski; Cheryl Ferraro; Thomas Washo; Daniel P Bonner
Journal:  Antimicrob Agents Chemother       Date:  2002-04       Impact factor: 5.191

4.  Bacterial pathogens isolated from patients with bloodstream infection: frequencies of occurrence and antimicrobial susceptibility patterns from the SENTRY antimicrobial surveillance program (United States and Canada, 1997).

Authors:  M A Pfaller; R N Jones; G V Doern; K Kugler
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191
  4 in total

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