Literature DB >> 11897597

Fourteen-member macrolides suppress interleukin-8 production but do not promote apoptosis of activated neutrophils.

Yoshiko Tsuchihashi1, Kazunori Oishi, Hiroyuki Yoshimine, Shoichi Suzuki, Atsushi Kumatori, Toshiaki Sunazuka, Satoshi Omura, Kouji Matsushima, Tsuyoshi Nagatake.   

Abstract

A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest that 14-member macrolides achieve clinical efficacy for chronic airway diseases partly by suppressing IL-8 production by activated neutrophils, but not by enhancing apoptosis in these cells.

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Year:  2002        PMID： 11897597      PMCID： PMC127094          DOI： 10.1128/AAC.46.4.1101-1104.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

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  6 in total

Review 1.  Pharmacological approaches to regulate neutrophil activity.

Authors:  G R Tintinger; R Anderson; C Feldman
Journal:  Semin Immunopathol       Date:  2013-03-15       Impact factor: 9.623

2.  Direct and indirect anti-inflammatory effects of tulathromycin in bovine macrophages: inhibition of CXCL-8 secretion, induction of apoptosis, and promotion of efferocytosis.

Authors:  Carrie D Fischer; Jennifer K Beatty; Stephanie C Duquette; Douglas W Morck; Merlyn J Lucas; André G Buret
Journal:  Antimicrob Agents Chemother       Date:  2013-01-07       Impact factor: 5.191

Review 3.  Mechanisms of action and clinical application of macrolides as immunomodulatory medications.

Authors:  Soichiro Kanoh; Bruce K Rubin
Journal:  Clin Microbiol Rev       Date:  2010-07       Impact factor: 26.132

4.  Anti-Inflammatory benefits of antibiotic-induced neutrophil apoptosis: tulathromycin induces caspase-3-dependent neutrophil programmed cell death and inhibits NF-kappaB signaling and CXCL8 transcription.

Authors:  Carrie D Fischer; Jennifer K Beatty; Cheryl G Zvaigzne; Douglas W Morck; Merlyn J Lucas; A G Buret
Journal:  Antimicrob Agents Chemother       Date:  2010-10-18       Impact factor: 5.191

5.  Fourteen-member macrolides promote the phosphatidylserine receptor-dependent phagocytosis of apoptotic neutrophils by alveolar macrophages.

Authors:  Takeshi Yamaryo; Kazunori Oishi; Hiroyuki Yoshimine; Yoshiko Tsuchihashi; Kouji Matsushima; Tsuyoshi Nagatake
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

6.  Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis.

Authors:  A P Watt; V Brown; J Courtney; M Kelly; L Garske; J S Elborn; M Ennis
Journal:  Thorax       Date:  2004-03       Impact factor: 9.139
  6 in total

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