| Literature DB >> 11897157 |
Mei Ling Chang1, Jun Yang, Seyha Kem, Lori Klaidman, Taku Sugawara, Pak H Chan, James D Adams.
Abstract
The possible ability of nicotinamide and ketamine to decrease infarction volume and DNA fragmentation was investigated in a middle cerebral artery occlusion rat model. DNA fragmentation was measured with an enzyme linked immunoassay. Control infarct volume was 223.8 +/- 10.6 mm(3). Ketamine alone did not alter infarct volume, 233.2 +/- 61.8 mm(3). Nicotinamide alone did not alter infarct volume, 235.2 +/- 62.8 mm(3). The combination of ketamine and nicotinamide decreased infarct volume to 83.8 +/- 35.2 mm(3). Ketamine produced hypothermia. Nicotinamide and ketamine decreased brain swelling and DNA fragmentation in the cerebral cortex, striatum and hippocampus in rats perfused for 6 or 24 h. Ketamine may synergize the actions of nicotinamide and partially prevent brain damage from ischemia and reperfusion.Entities:
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Year: 2002 PMID： 11897157 DOI： 10.1016/s0304-3940(01)02520-4
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046