BACKGROUND: Vascular endothelial growth factor (VEGF) is a multifunctional angiogenic cytokine involved in angiogenesis and wound healing. Its presence in recurrent aphthous ulceration has not been reported to date. The aim of this study was to investigate the association of salivary levels of VEGF with various stages of recurrent aphthous ulceration (RAU). METHODS: VEGF levels were determined in a group of 27 age and sex-matched healthy controls and in 30 patients with minor and major RAU grouped into the three stages: (I) early active stage, (II) active stage, and (III) remission period. VEGF levels (pg/ml; mean +/- SD) in unstimulated whole saliva were determined by enzyme immunoassay. RESULTS: Patients with major RAU - stages I and II - had decreased VEGF values (765 +/- 458 and 341 +/- 109, respectively) when compared both to healthy controls (1652 +/- 567; P < 0.01) and to stage III major RAU (1524 +/- 784; P < 0.005). CONCLUSION: Salivary VEGF levels seemed to be associated with ulcer development in major RAU, showing stage-dependent alterations during the course of this disorder.
BACKGROUND:Vascular endothelial growth factor (VEGF) is a multifunctional angiogenic cytokine involved in angiogenesis and wound healing. Its presence in recurrent aphthous ulceration has not been reported to date. The aim of this study was to investigate the association of salivary levels of VEGF with various stages of recurrent aphthous ulceration (RAU). METHODS:VEGF levels were determined in a group of 27 age and sex-matched healthy controls and in 30 patients with minor and major RAU grouped into the three stages: (I) early active stage, (II) active stage, and (III) remission period. VEGF levels (pg/ml; mean +/- SD) in unstimulated whole saliva were determined by enzyme immunoassay. RESULTS:Patients with major RAU - stages I and II - had decreased VEGF values (765 +/- 458 and 341 +/- 109, respectively) when compared both to healthy controls (1652 +/- 567; P < 0.01) and to stage III major RAU (1524 +/- 784; P < 0.005). CONCLUSION: Salivary VEGF levels seemed to be associated with ulcer development in major RAU, showing stage-dependent alterations during the course of this disorder.
Authors: Sundeep G Keswani; Swathi Balaji; Louis D Le; Alice Leung; Jignesh K Parvadia; Jason Frischer; Seiichi Yamano; Norton Taichman; Timothy M Crombleholme Journal: Wound Repair Regen Date: 2013-06-11 Impact factor: 3.617
Authors: Adrià Aterido; Antonio Julià; Patricia Carreira; Ricardo Blanco; José Javier López-Longo; José Javier Pérez Venegas; Àlex Olivé; José Luís Andreu; Maria Ángeles Aguirre-Zamorano; Paloma Vela; Joan M Nolla; José Luís Marenco-de la Fuente; Antonio Zea; José María Pego; Mercedes Freire; Elvira Díez; María López-Lasanta; Mireia López-Corbeto; Núria Palau; Raül Tortosa; Josep Lluís Gelpí; Devin Absher; Richard M Myers; Antonio Fernández-Nebro; Sara Marsal Journal: Arthritis Res Ther Date: 2017-06-15 Impact factor: 5.156