| Literature DB >> 11895388 |
Chuljin Ahn1, Reuben Correia, Philip DeShong.
Abstract
The Mitsunobu reaction occurs typically with inversion of configuration in secondary alcohol derivatives. In this paper, a mechanistic explanation for lactonizations of hindered alcohols under Mitsunobu conditions with retention is proposed. This involves the intermediacy of an acyloxyphosphonium salt followed by acyl transfer to the alcohol.Entities:
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Year: 2002 PMID： 11895388 DOI： 10.1021/jo001590m
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354