Literature DB >> 11895384

Twin studies in behavioral research: a skeptical view.

Leon J Kamin1, Arthur S Goldberger.   

Abstract

We review in detail two major ongoing research projects that employ samples of twins reared apart (and in one case, twins reared together). The studies attempt, via model fitting, to estimate proportions of genetic and environmental variance for many human traits. We discuss problems concerning the representativeness of samples, the accuracy and reliability of the data, the extent of contact of nominally separated twins, the measurement of selective placement effects, and the particular model-fitting procedures. The two studies agree in their conclusions, but we do not find the conclusions to be convincing. We suggest that no scientific purpose is served by the flood of heritability estimates generated by these studies.

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Year:  2002        PMID: 11895384     DOI: 10.1006/tpbi.2001.1555

Source DB:  PubMed          Journal:  Theor Popul Biol        ISSN: 0040-5809            Impact factor:   1.570


  6 in total

1.  Genetic evidence for natural selection in humans in the contemporary United States.

Authors:  Jonathan P Beauchamp
Journal:  Proc Natl Acad Sci U S A       Date:  2016-07-11       Impact factor: 11.205

Review 2.  The role of genetics in the etiology of schizophrenia.

Authors:  Pablo V Gejman; Alan R Sanders; Jubao Duan
Journal:  Psychiatr Clin North Am       Date:  2010-03

3.  Environment-sensitive epigenetics and the heritability of complex diseases.

Authors:  Robert E Furrow; Freddy B Christiansen; Marcus W Feldman
Journal:  Genetics       Date:  2011-10-03       Impact factor: 4.562

4.  Genome-wide polygenic scoring for a 14-year long-term average depression phenotype.

Authors:  Shun-Chiao Chang; M Maria Glymour; Stefan Walter; Liming Liang; Karestan C Koenen; Eric J Tchetgen; Marilyn C Cornelis; Ichiro Kawachi; Eric Rimm; Laura D Kubzansky
Journal:  Brain Behav       Date:  2014-02-12       Impact factor: 2.708

5.  Jumping on the Train of Personalized Medicine: A Primer for Non-Geneticist Clinicians: Part 2. Fundamental Concepts in Genetic Epidemiology.

Authors:  Aihua Li; David Meyre
Journal:  Curr Psychiatry Rev       Date:  2014-05

Review 6.  The 'fractionable autism triad': a review of evidence from behavioural, genetic, cognitive and neural research.

Authors:  Francesca Happé; Angelica Ronald
Journal:  Neuropsychol Rev       Date:  2008-10-28       Impact factor: 7.444

  6 in total

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