Literature DB >> 11895135

Alpha2-adrenergic receptor agonists as analgesics.

R E Boyd1.   

Abstract

Alpha2-adrenergic receptor agonists are analgesic agents, and the alpha2-adrenergic agonist clonidine has been used in clinical studies for regional analgesia after intrathecal administration. We review here recent developments concerning the structure activity relationships of a new class of potent alpha2-adrenergic agonists and their use as analgesic agents. The effect of structure upon cardiovascular side-effects is also monitored, such as the prolongation of the QT portion of the cardiac action potential.

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Year:  2001        PMID： 11895135     DOI： 10.2174/1568026013395182

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  5 in total

Review 1.  Opioid analgesics and P-glycoprotein efflux transporters: a potential systems-level contribution to analgesic tolerance.

Authors:  Susan L Mercer; Andrew Coop
Journal:  Curr Top Med Chem       Date:  2011       Impact factor: 3.295

2.  Noradrenergic agonist administration into the central nucleus of the amygdala increases the tail-flick latency in lightly anesthetized rats.

Authors:  J P Ortiz; M M Heinricher; N R Selden
Journal:  Neuroscience       Date:  2007-07-12       Impact factor: 3.590

Review 3.  The perioperative management of pain from intracranial surgery.

Authors:  Allan Gottschalk; Myron Yaster
Journal:  Neurocrit Care       Date:  2008-10-01       Impact factor: 3.210

Review 4.  Biased, Bitopic, Opioid-Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction.

Authors:  Robert Root-Bernstein
Journal:  Pharmaceuticals (Basel)       Date:  2022-02-10

5.  Effects of perineural administration of dexmedetomidine in combination with bupivacaine in a femoral-sciatic nerve block.

Authors:  Safaa M Helal; Ashraf M Eskandr; Khaled M Gaballah; Ihab S Gaarour
Journal:  Saudi J Anaesth       Date:  2016 Jan-Mar
  5 in total

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