Literature DB >> 11895077

Novel approaches to tackling malarial drug resistance using yeast.

C H Sibley1, I Macreadie.   

Abstract

Yeasts have a justified reputation as one of the world's most versatile organisms. Baker's yeast continues to live up to this recognition by joining the war against malaria. Yeast can now be used to study antifolate drug resistance patterns that depend on the dihydrofolate reductase enzyme (DHFR) from the malaria parasite.

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Year:  2001        PMID： 11895077     DOI： 10.1080/152165401317291138

Source DB:  PubMed          Journal:  IUBMB Life        ISSN： 1521-6543            Impact factor:   3.885


  5 in total

1.  Compensatory mutations restore fitness during the evolution of dihydrofolate reductase.

Authors:  Kyle M Brown; Marna S Costanzo; Wenxin Xu; Scott Roy; Elena R Lozovsky; Daniel L Hartl
Journal:  Mol Biol Evol       Date:  2010-06-24       Impact factor: 16.240

2.  Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.

Authors:  Sasinee Bunyarataphan; Ubolsree Leartsakulpanich; Supannee Taweechai; Bongkoch Tarnchompoo; Sumalee Kamchonwongpaisan; Yongyuth Yuthavong
Journal:  Antimicrob Agents Chemother       Date:  2006-09-05       Impact factor: 5.191

3.  Stepwise acquisition of pyrimethamine resistance in the malaria parasite.

Authors:  Elena R Lozovsky; Thanat Chookajorn; Kyle M Brown; Mallika Imwong; Philip J Shaw; Sumalee Kamchonwongpaisan; Daniel E Neafsey; Daniel M Weinreich; Daniel L Hartl
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-08       Impact factor: 11.205

Review 4.  Heterologous expression of plasmodial proteins for structural studies and functional annotation.

Authors:  Lyn-Marie Birkholtz; Gregory Blatch; Theresa L Coetzer; Heinrich C Hoppe; Esmaré Human; Elizabeth J Morris; Zoleka Ngcete; Lyndon Oldfield; Robyn Roth; Addmore Shonhai; Linda Stephens; Abraham I Louw
Journal:  Malar J       Date:  2008-10-01       Impact factor: 2.979

5.  Relevance of Higher-Order Epistasis in Drug Resistance.

Authors:  Elena R Lozovsky; Rachel F Daniels; Gavin D Heffernan; David P Jacobus; Daniel L Hartl
Journal:  Mol Biol Evol       Date:  2021-01-04       Impact factor: 16.240
  5 in total

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