Literature DB >> 11894776

The effects of ototoxic drugs on mechano-electric transduction channels in chick cochlear hair cells.

T Kimitsuki1, T Nakagawa, K Hisashi, S Komune, T Uemura.   

Abstract

The effects of ototoxic drugs on mechano-electrical transduction (MET) currents were investigated in dissociated cochlear hair cells of the chick, using a whole-cell patch-electrode voltage-clamp technique. Dihydrostreptomycin (DHSM) and cisplatin (cis-dichlorodiammine platinum II, CDDP) blocked the MET channel in a dose- and voltage-dependent manner. In contrast, acetyl salicylate did not suppress the MET current. At -50 mV, DHSM and CDDP blocked the MET channel with a Hill coefficient of 0.93 and 2.1, respectively. These findings suggest that a single DHSM molecule or more than one CDDP molecule binds to a single MET channel.

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Year:  1994        PMID： 11894776     DOI： 10.1007/bf02565220

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  17 in total

1.  Blockage of the transduction channels of hair cells in the bullfrog's sacculus by aminoglycoside antibiotics.

Authors:  A B Kroese; A Das; A J Hudspeth
Journal:  Hear Res       Date:  1989-02       Impact factor: 3.208

2.  Experiments on ototoxic effects of antibiotics.

Authors:  J Wersäll; B Björkroth; A Flock; P G Lundquist
Journal:  Adv Otorhinolaryngol       Date:  1973

3.  Choline salicylate. Effects on cochlear function.

Authors:  D L McPherson; J M Miller
Journal:  Arch Otolaryngol       Date:  1974-04

4.  Effects of streptomycin, kanamycin, quinine, and other drugs on the microphonic potentials of goldfish sacculus.

Authors:  S Matsuura; K Ikeda; T Furukawa
Journal:  Jpn J Physiol       Date:  1971-10

5.  Amiloride blocks the mechano-electrical transduction channel of hair cells of the chick.

Authors:  F Jørgensen; H Ohmori
Journal:  J Physiol       Date:  1988-09       Impact factor: 5.182

6.  Mechanisms of salicylate ototoxicity.

Authors:  P H Stypulkowski
Journal:  Hear Res       Date:  1990-06       Impact factor: 3.208

7.  Mechano-electrical transduction currents in isolated vestibular hair cells of the chick.

Authors:  H Ohmori
Journal:  J Physiol       Date:  1985-02       Impact factor: 5.182

8.  Comparative actions of salicylate on the amphibian lateral line and guinea pig cochlea.

Authors:  J L Puel; S C Bledsoe; R P Bobbin; G Ceasar; M Fallon
Journal:  Comp Biochem Physiol C Comp Pharmacol Toxicol       Date:  1989

9.  Studies of ionic currents in the isolated vestibular hair cell of the chick.

Authors:  H Ohmori
Journal:  J Physiol       Date:  1984-05       Impact factor: 5.182

10.  The effect of caged calcium release on the adaptation of the transduction current in chick hair cells.

Authors:  T Kimitsuki; H Ohmori
Journal:  J Physiol       Date:  1992-12       Impact factor: 5.182
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  2 in total

Review 1.  Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.

Authors:  Corné J Kros; Peter S Steyger
Journal:  Cold Spring Harb Perspect Med       Date:  2019-11-01       Impact factor: 6.915

2.  [Acetylsalicylic acid does not alter the mechanoelectrical transduction of mammalian outer hair cells in vitro].

Authors:  S Preyer; J Meyer
Journal:  HNO       Date:  2006-09       Impact factor: 1.284
  2 in total

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