Literature DB >> 1189457

Levels of piribedil and its active metabolite (S-584) in the rat striatum.

R Fanelli, A Frigerio, S Garattini.   

Abstract

1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.

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Year:  1975        PMID： 1189457     DOI： 10.3109/00498257509056129

Source DB:  PubMed          Journal:  Xenobiotica        ISSN： 0049-8254            Impact factor:   1.908


  2 in total

1.  Solid-phase extraction of piribedil and its metabolites from plasma and urine without and after deconjugation, by high performance liquid chromatography.

Authors:  S Sarati; S Caccia
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1992 Jul-Sep       Impact factor: 2.441

2.  Kinetics of piribedil and effects on dopamine metabolism: hepatic biotransformation is not a determinant of its dopaminergic action in rats.

Authors:  S Sarati; G Guiso; S Garattini; S Caccia
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530
  2 in total

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