| Literature DB >> 11894117 |
Noriyasu Uwatoko1, Tetsuji Tokunaga, Hiroyuki Hatanaka, Hideo Osada, Tsutomu Kawakami, Hitoshi Yamazaki, Yoshiyuki Abe, Hiroshi Kijima, Yoshito Ueyama, Masato Nakamura.
Abstract
Interleukin-10 (IL-10) is an immunomodulative cytokine produced by T cells, B cells, and monocytic cells. The significance of IL-10 and IL-10R expression in renal cell carcinoma (RCC) has not been well characterized. In this study, we assessed the correlation between IL-10 gene expression and its pathological significance in 44 RCC specimens. The patients with IL-10 gene expression showed a decreased incidence of metastasis compared to those without IL-10 gene expression. The expression of IL-10 was correlated with vascular endothelial growth factor (VEGF)-A gene expression. These findings suggest that IL-10 gene expression plays some roles in the metastasis of RCC.Entities:
Mesh：
Substances：
Year: 2002 PMID： 11894117
Source DB: PubMed Journal: Int J Oncol ISSN： 1019-6439 Impact factor: 5.650