Literature DB >> 11893546

The impact of microwave-assisted organic chemistry on drug discovery.

Bernard Wathey1, Jason Tierney, Pelle Lidström, Jacob Westman.   

Abstract

Microwave-assisted organic synthesis (MAOS) is rapidly becoming recognized as a valuable tool for easing some of the bottlenecks in the drug discovery process. This article outlines the basic principles behind the technology and summarizes the areas in which microwave technology has made an impact, to date.

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Year:  2002        PMID： 11893546     DOI： 10.1016/s1359-6446(02)02178-5

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  13 in total

Review 1.  Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

2.  Microwave-assisted synthesis of a 3-aminoimidazo[1,2-a]-pyridine/pyrazine library by fluorous multicomponent reactions and subsequent cross-coupling reactions.

Authors:  Yimin Lu; Wei Zhang
Journal:  QSAR Comb Sci       Date:  2004

3.  Microwave-Assisted Synthesis of N-Phenylsuccinimide.

Authors:  Thomas A Shell; Jennifer R Shell; Kathleen A Poole; Thomas F Guetzloff
Journal:  J Chem Educ       Date:  2011-10-01       Impact factor: 2.979

4.  Open vessel mode microwave-assisted synthesis of 2-oxazolines from carboxylic acids.

Authors:  Rishi Sharma; Subramanian K Vadivel; Richard I Duclos; Alexandros Makriyannis
Journal:  Tetrahedron Lett       Date:  2009-10-21       Impact factor: 2.415

5.  Combination of microwave reactions with fluorous separations in the palladium-catalyzed synthesis of aryl sulfides.

Authors:  Wei Zhang; Yimin Lu; Christine Hiu-Tung Chen
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

6.  Microwave-enhanced liquid-phase synthesis of thiohydantoins and thioxotetrahydropyrimidinones.

Authors:  Wen-Ben Yeh; Mei-Jung Lin; Ming-Juan Lee; Chung-Ming Sun
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

7.  Novel microwave-assisted synthesis of the immunomodulator organotellurium compound ammonium trichloro(dioxoethylene-O,O')tellurate (AS101).

Authors:  M Pilar Vázquez-Tato; Alberto Mena-Menéndez; Xesús Feás; Julio A Seijas
Journal:  Int J Mol Sci       Date:  2014-02-21       Impact factor: 5.923

Review 8.  Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles.

Authors:  Marco Colella; Leonardo Degennaro; Renzo Luisi
Journal:  Molecules       Date:  2020-07-16       Impact factor: 4.411

9.  Novel 2-Hydroselenonicotinonitriles and Selenopheno[2, 3-b]pyridines: Efficient Synthesis, Molecular Docking-DFT Modeling, and Antimicrobial Assessment.

Authors:  Magda H Abdellattif; Adel A H Abdel-Rahman; Mohamed Mohamed Helmy Arief; Samar M Mouneir; Amena Ali; Mostafa A Hussien; Rawda M Okasha; Tarek H Afifi; Mohamed Hagar
Journal:  Front Chem       Date:  2021-05-10       Impact factor: 5.221

10.  Optimizing the Synthetic Route of Chromone-2-carboxylic Acids: A Step forward to Speed-Up the Discovery of Chromone-Based Multitarget-Directed Ligands.

Authors:  Fernando Cagide; Catarina Oliveira; Joana Reis; Fernanda Borges
Journal:  Molecules       Date:  2019-11-20       Impact factor: 4.411
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