Literature DB >> 11893195

Mutational analysis of the enterocin favorskii biosynthetic rearrangement.

Longkuan Xiang1, John A Kalaitzis, George Nilsen, Li Chen, Bradley S Moore.   

Abstract

[reaction: see text] A mutational analysis of the enterocin biosynthesis genes revealed that the putative oxygenase and the methyltransferase gene products EncM and EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported.

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Year:  2002        PMID： 11893195     DOI： 10.1021/ol0255155

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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