OBJECTIVE: To evaluate the effectiveness of influenza vaccines against influenza-like illness (ILI) among nursing home residents. DESIGN: Prospective, nonrandomized, cohort study. SETTING: Nine nursing homes during the 1998-1999 influenza season and 11 nursing homes during the 1999-2000 influenza season in Niigata Prefecture, Japan. PARTICIPANTS: Six hundred ninety-nine residents and 440 healthcare workers (HCWs) during the first season, and 930 residents and 517 HCWs during the second season, with vaccination rates ranging from 0% to 97.7%. RESULTS: Overall, ILI decreased from 24.3% during the 1998-1999 season to 8.8% during the 1999-2000 season. Multivariate analysis adjusted for several factors, including gender, age, underlying diseases, and resident and HCW vaccination rates, failed to demonstrate clear individual protection of residents (relative risk [RR], 1.42; P = .2 for the first season; RR, 0.95; P = .9 for the second season). However, vaccination rates of 60% or greater for residents and HCWs reduced the risk of ILI, and also could prevent outbreaks during the 2 seasons. Highly impaired activities of daily living and chronic respiratory diseases were significantly associated with increased ILI. CONCLUSIONS: A high vaccination rate for both residents and HCWs may reduce the risk of ILI and institutional outbreaks in nursing homes.
OBJECTIVE: To evaluate the effectiveness of influenza vaccines against influenza-like illness (ILI) among nursing home residents. DESIGN: Prospective, nonrandomized, cohort study. SETTING: Nine nursing homes during the 1998-1999 influenza season and 11 nursing homes during the 1999-2000 influenza season in Niigata Prefecture, Japan. PARTICIPANTS: Six hundred ninety-nine residents and 440 healthcare workers (HCWs) during the first season, and 930 residents and 517 HCWs during the second season, with vaccination rates ranging from 0% to 97.7%. RESULTS: Overall, ILI decreased from 24.3% during the 1998-1999 season to 8.8% during the 1999-2000 season. Multivariate analysis adjusted for several factors, including gender, age, underlying diseases, and resident and HCW vaccination rates, failed to demonstrate clear individual protection of residents (relative risk [RR], 1.42; P = .2 for the first season; RR, 0.95; P = .9 for the second season). However, vaccination rates of 60% or greater for residents and HCWs reduced the risk of ILI, and also could prevent outbreaks during the 2 seasons. Highly impaired activities of daily living and chronic respiratory diseases were significantly associated with increased ILI. CONCLUSIONS: A high vaccination rate for both residents and HCWs may reduce the risk of ILI and institutional outbreaks in nursing homes.
Authors: Andrew C Hayward; Richard Harling; Sally Wetten; Anne M Johnson; Susan Munro; Julia Smedley; Shahed Murad; John M Watson Journal: BMJ Date: 2006-12-01
Authors: M Cristina Ajenjo; Keith F Woeltje; Hilary M Babcock; Nancy Gemeinhart; Marilyn Jones; Victoria J Fraser Journal: Infect Control Hosp Epidemiol Date: 2010-03 Impact factor: 3.254
Authors: Gayle P Dolan; Rebecca C Harris; Mandy Clarkson; Rachel Sokal; Gemma Morgan; Mitsuru Mukaigawara; Hiroshi Horiuchi; Rachel Hale; Laura Stormont; Laura Béchard-Evans; Yi-Sheng Chao; Sergey Eremin; Sara Martins; John Tam; Javier Peñalver; Arina Zanuzadana; Jonathan S Nguyen-Van-Tam Journal: Influenza Other Respir Viruses Date: 2013-09 Impact factor: 4.380
Authors: Gayle P Dolan; Rebecca C Harris; Mandy Clarkson; Rachel Sokal; Gemma Morgan; Mitsuru Mukaigawara; Hiroshi Horiuchi; Rachel Hale; Laura Stormont; Laura Béchard-Evans; Yi-Sheng Chao; Sergey Eremin; Sara Martins; John S Tam; Javier Peñalver; Arina Zanuzdana; Arina Zanuzadana; Jonathan S Nguyen-Van-Tam Journal: Emerg Infect Dis Date: 2012-08 Impact factor: 6.883
Authors: Vittorio Demicheli; Tom Jefferson; Carlo Di Pietrantonj; Eliana Ferroni; Sarah Thorning; Roger E Thomas; Alessandro Rivetti Journal: Cochrane Database Syst Rev Date: 2018-02-01