Literature DB >> 11892008

A Cre/loxP-deleter transgenic line in mouse strain 129S1/SvImJ.

Shih-Huey E Tang1, Francisco J Silva, Walter M K Tsark, Jeffrey R Mann.   

Abstract

A Cre recombinase expression cassette was inserted into the X-linked Hprt locus by gene targeting in a mouse embryonic stem (ES) cell line isogenic to strain 129S1/SvImJ (129S1), then the transgene was introduced into 129S1 mice through ES cell chimeras. When females hemizygous for this transgene were mated to males carrying a neomycin selection cassette flanked by loxP sites, the cassette was always excised regardless of Cre inheritance and without detectable mosaicism. The usefulness of this "Cre-deleter" transgenic line is in its efficiency and defined genetic status in terms of mouse strain and location of the transgene. Copyright 2002 Wiley-Liss, Inc.

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Year:  2002        PMID： 11892008     DOI： 10.1002/gene.10030

Source DB:  PubMed          Journal:  Genesis        ISSN： 1526-954X            Impact factor:   2.487


  105 in total

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