Literature DB >> 11891120

Roles of PI3Ks in leukocyte chemotaxis and phagocytosis.

Len Stephens1, Chris Ellson, Phillip Hawkins.   

Abstract

Through selective disruption of phosphoinositide 3-kinase (PI3K) activity and the use of green fluorescent protein tagged derivatives of domains capable of specifically binding the lipid products of PI3Ks in vivo, it has been shown that this family of signalling enzymes have vital and distinct roles in chemotaxis, phagocytosis and phagosome maturation in leukocytes.

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Year:  2002        PMID： 11891120     DOI： 10.1016/s0955-0674(02)00311-3

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  74 in total

1.  Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells.

Authors:  Yi Elaine Huang; Miho Iijima; Carole A Parent; Satoru Funamoto; Richard A Firtel; Peter Devreotes
Journal:  Mol Biol Cell       Date:  2003-02-06       Impact factor: 4.138

Review 2.  Signaling pathways at the leading edge of chemotaxing cells.

Authors:  Chang Y Chung; Richard A Firtel
Journal:  J Muscle Res Cell Motil       Date:  2002       Impact factor: 2.698

Review 3.  Phagosome maturation: a few bugs in the system.

Authors:  C C Scott; R J Botelho; S Grinstein
Journal:  J Membr Biol       Date:  2003-06-01       Impact factor: 1.843

Review 4.  Emerging mechanisms of neutrophil recruitment across endothelium.

Authors:  Marcie R Williams; Verónica Azcutia; Gail Newton; Pilar Alcaide; Francis W Luscinskas
Journal:  Trends Immunol       Date:  2011-08-11       Impact factor: 16.687

5.  Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation.

Authors:  Yong I Cha; Seok-Hyung Kim; Diane Sepich; F Gregory Buchanan; Lilianna Solnica-Krezel; Raymond N DuBois
Journal:  Genes Dev       Date:  2006-01-01       Impact factor: 11.361

Review 6.  Lysosomal membrane proteomics and biogenesis of lysosomes.

Authors:  Richard D Bagshaw; Don J Mahuran; John W Callahan
Journal:  Mol Neurobiol       Date:  2005-08       Impact factor: 5.590

7.  Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: role of 12/15-lipoxygenase and phosphoinositide 3-kinase.

Authors:  Yury I Miller; Dorothy S Worrall; Colin D Funk; James R Feramisco; Joseph L Witztum
Journal:  Mol Biol Cell       Date:  2003-07-11       Impact factor: 4.138

8.  Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1.

Authors:  Wendy A Kimber; Maria Deak; Alan R Prescott; Dario R Alessi
Journal:  Biochem J       Date:  2003-12-01       Impact factor: 3.857

9.  Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway.

Authors:  M-J Don; J-F Liao; L-Y Lin; W-F Chiou
Journal:  Br J Pharmacol       Date:  2007-04-30       Impact factor: 8.739

10.  TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.

Authors:  Susan Lee; Frank I Comer; Atsuo Sasaki; Ian X McLeod; Yung Duong; Koichi Okumura; John R Yates; Carole A Parent; Richard A Firtel
Journal:  Mol Biol Cell       Date:  2005-08-03       Impact factor: 4.138
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