| Literature DB >> 11890765 |
Long-Cheng Wang1, Ana Liza Luis, Kyriacos Agapiou, Hye-Young Jang, Michael J Krische.
Abstract
The utilization of enones as latent enolates enables regioselective enolate formation from chemically robust presursors. In this communication, we report a catalytic Michael cycloisomerization of bis(enones) under Morita-Baylis-Hillman conditions. Upon exposure to 10 mol % tributylphosphine, bis(enone) substrates afford both five- and six-membered ring products. Notably, unsymmetrical bis(enones) possessing sufficient steric or electronic bias yield single isomeric products.Entities:
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Year: 2002 PMID： 11890765 DOI： 10.1021/ja0121686
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419