OBJECTIVE: Structural differences of the pulmonary root may predispose it to progressive dilatation in the systemic circulation after the Ross operation. We identified the incidence and risk factors of pulmonary autograft root dilatation. METHODS: One hundred and seven adult patients (mean age of 36+/-11 years) were followed after the Ross operation since 1991 including an echocardiogram within 3 months of surgery and yearly clinical assessment and echocardiography. The autograft was measured at the maximum diameter of the sinus (SV) and aortic insufficiency (AI) assessed. A SV of >37 mm was considered as root dilatation and the incidence over time was calculated using the Kaplan-Meier method. Clinically relevant dilatation was defined as a root diameter of >42 mm. In addition, we determined the percentage change of the sinus diameter between the early and latest echocardiogram. Furthermore we tested the influence of patient variables and risk factors on dilatation. RESULTS: By 1 year, dilatation was found in 21 patients (20%). The SV was >42 mm in eight patients (7%). By 7 years, only 45% of patients were free of dilatation. Eleven patients (10%) had a SV of >42 mm. Increase in SV was time related and linear. However, 90% of patients showed <25% dilatation during follow-up. Time from operation, early SV diameter, male gender and surgical technique were identified as significant risk factors of dilatation. However, dilatation has not lead to reoperation due to aneurysm formation or development of significant AI. CONCLUSIONS: We conclude that time dependent autograft root dilation occurs but does not cause an increase in AI and need for reoperation up to 7 years. These findings warrant the pursuit of the concept of the Ross operation in young patients who regain excellent functional status and life style without anticoagulation.
OBJECTIVE: Structural differences of the pulmonary root may predispose it to progressive dilatation in the systemic circulation after the Ross operation. We identified the incidence and risk factors of pulmonary autograft root dilatation. METHODS: One hundred and seven adult patients (mean age of 36+/-11 years) were followed after the Ross operation since 1991 including an echocardiogram within 3 months of surgery and yearly clinical assessment and echocardiography. The autograft was measured at the maximum diameter of the sinus (SV) and aortic insufficiency (AI) assessed. A SV of >37 mm was considered as root dilatation and the incidence over time was calculated using the Kaplan-Meier method. Clinically relevant dilatation was defined as a root diameter of >42 mm. In addition, we determined the percentage change of the sinus diameter between the early and latest echocardiogram. Furthermore we tested the influence of patient variables and risk factors on dilatation. RESULTS: By 1 year, dilatation was found in 21 patients (20%). The SV was >42 mm in eight patients (7%). By 7 years, only 45% of patients were free of dilatation. Eleven patients (10%) had a SV of >42 mm. Increase in SV was time related and linear. However, 90% of patients showed <25% dilatation during follow-up. Time from operation, early SV diameter, male gender and surgical technique were identified as significant risk factors of dilatation. However, dilatation has not lead to reoperation due to aneurysm formation or development of significant AI. CONCLUSIONS: We conclude that time dependent autograft root dilation occurs but does not cause an increase in AI and need for reoperation up to 7 years. These findings warrant the pursuit of the concept of the Ross operation in young patients who regain excellent functional status and life style without anticoagulation.