Literature DB >> 11888020

Quantitation of organophosphorus nerve agent metabolites in human urine using isotope dilution gas chromatography-tandem mass spectrometry.

W Jack Driskell1, Ming Shih, Larry L Needham, Dana B Barr.   

Abstract

An isotope dilution gas chromatography-tandem mass spectrometric (GC-MS-MS) method was developed for quantitating the urinary metabolites of the organophosphorus nerve agents sarin, soman, tabun (GA), VX, and GF. Urine samples were concentrated by codistillation with acetonitrile, derivatized by methylation with diazomethane, and analyzed by GC-MS-MS. The limits of detection were less than 4 microg/L for all the analytes except for the GA metabolite, which had a limit of detection of less than 20 microg/L.

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Year:  2002        PMID： 11888020     DOI： 10.1093/jat/26.1.6

Source DB:  PubMed          Journal:  J Anal Toxicol        ISSN： 0146-4760            Impact factor:   3.367


  8 in total

1.  Detection of aqueous phase chemical warfare agent degradation products by negative mode ion mobility time-of-flight mass spectrometry [IM(tof)MS].

Authors:  Wes E Steiner; Charles S Harden; Feng Hong; Steve J Klopsch; Herbert H Hill; Vincent M McHugh
Journal:  J Am Soc Mass Spectrom       Date:  2006-01-18       Impact factor: 3.109

2.  Quantitation of five organophosphorus nerve agent metabolites in serum using hydrophilic interaction liquid chromatography and tandem mass spectrometry.

Authors:  Elizabeth I Hamelin; Nicholas D Schulze; Rebecca L Shaner; Rebecca M Coleman; Richard J Lawrence; Brian S Crow; E M Jakubowski; Rudolph C Johnson
Journal:  Anal Bioanal Chem       Date:  2014-03-15       Impact factor: 4.142

3.  Comparison of high-resolution and tandem mass spectrometry for the analysis of nerve agent metabolites in urine.

Authors:  Elizabeth I Hamelin; William Bragg; Rebecca L Shaner; Leigh L Swaim; Rudolph C Johnson
Journal:  Rapid Commun Mass Spectrom       Date:  2013-08-15       Impact factor: 2.419

4.  Investigation of dried blood sampling with liquid chromatography tandem mass spectrometry to confirm human exposure to nerve agents.

Authors:  Rebecca L Shaner; Rebecca M Coleman; Nicholas Schulze; Kelsey Platanitis; Ashli A Brown; Craig Seymour; Pearl Kaplan; Jonas Perez; Elizabeth I Hamelin; Rudolph C Johnson
Journal:  Anal Chim Acta       Date:  2018-06-20       Impact factor: 6.558

5.  Bridging the Gap between Sample Collection and Laboratory Analysis: Using Dried Blood Spots to Identify Human Exposure to Chemical Agents.

Authors:  Elizabeth I Hamelin; Thomas A Blake; Jonas W Perez; Brian S Crow; Rebecca L Shaner; Rebecca M Coleman; Rudolph C Johnson
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2016-05-13

6.  Computational design of receptors for an organophosphate surrogate of the nerve agent soman.

Authors:  Malin Allert; Shahir S Rizk; Loren L Looger; Homme W Hellinga
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-17       Impact factor: 11.205

7.  Competitive FRET-aptamer-based detection of methylphosphonic acid, a common nerve agent metabolite.

Authors:  John G Bruno; Maria P Carrillo; Taylor Phillips; Neal K Vail; Douglas Hanson
Journal:  J Fluoresc       Date:  2008-01-26       Impact factor: 2.217

Review 8.  Acetylcholinesterase: The "Hub" for Neurodegenerative Diseases and Chemical Weapons Convention.

Authors:  Samir F de A Cavalcante; Alessandro B C Simas; Marcos C Barcellos; Victor G M de Oliveira; Roberto B Sousa; Paulo A de M Cabral; Kamil Kuča; Tanos C C França
Journal:  Biomolecules       Date:  2020-03-07
  8 in total

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