OBJECTIVE: To evaluate possible adverse reproductive outcomes in an area adjacent to a petrochemical plant in southern Brazil. METHODS: A review of 17,113 birth records of the main hospital of the municipality of Montenegro, southern Brazil, from 1983 to 1998 was carried out. Three groups of cases were selected: (1) newborns with major congenital malformations; (2) newborns with low birth weight (<2,500 g); and (3) stillborns (>500 g). A control was assigned to each case. Controls were the first newborns weighing </= 12,500 g without malformations and of case-matching sex. Mother's residence during pregnancy was used as an exposure parameter. Statistical analyses were performed using Chi-square test or Fisher test, odds ratio, 0.05 significance level, and 95% confidence interval. RESULTS: For unadjusted analysis, it was found a correlation between low birth weight and geographical proximity of mother's residence to the petrochemical plant (OR = 1.66; 95% CI = 1.01 - 2.72) or residence on the way of preferential wind direction (OR = 1.62; 95% CI = 1.03 - 2.56). When other covariates were added in the conditional logistic regression (maternal smoking habits, chronic disease and age), there was no association. CONCLUSIONS: Despite final results were negative, low birth weight could be a good parameter of environmental contamination and should be closely monitored in the studied area.
OBJECTIVE: To evaluate possible adverse reproductive outcomes in an area adjacent to a petrochemical plant in southern Brazil. METHODS: A review of 17,113 birth records of the main hospital of the municipality of Montenegro, southern Brazil, from 1983 to 1998 was carried out. Three groups of cases were selected: (1) newborns with major congenital malformations; (2) newborns with low birth weight (<2,500 g); and (3) stillborns (>500 g). A control was assigned to each case. Controls were the first newborns weighing </= 12,500 g without malformations and of case-matching sex. Mother's residence during pregnancy was used as an exposure parameter. Statistical analyses were performed using Chi-square test or Fisher test, odds ratio, 0.05 significance level, and 95% confidence interval. RESULTS: For unadjusted analysis, it was found a correlation between low birth weight and geographical proximity of mother's residence to the petrochemical plant (OR = 1.66; 95% CI = 1.01 - 2.72) or residence on the way of preferential wind direction (OR = 1.62; 95% CI = 1.03 - 2.56). When other covariates were added in the conditional logistic regression (maternal smoking habits, chronic disease and age), there was no association. CONCLUSIONS: Despite final results were negative, low birth weight could be a good parameter of environmental contamination and should be closely monitored in the studied area.
Authors: Adela Castelló; Isabel Río; Javier García-Pérez; Pablo Fernández-Navarro; Lance A Waller; Julie A Clennon; Francisco Bolúmar; Gonzalo López-Abente Journal: Environ Sci Pollut Res Int Date: 2013-01-16 Impact factor: 4.223
Authors: Victoria D Balise; Chun-Xia Meng; Jennifer N Cornelius-Green; Christopher D Kassotis; Rana Kennedy; Susan C Nagel Journal: Fertil Steril Date: 2016-08-25 Impact factor: 7.329
Authors: Lavinia Schüler-Faccini; Maria Teresa Vieira Sanseverino; Alberto Mantovani Abeche; Fernanda Sales Luiz Vianna; Lucas Rosa Fraga; Anastacia Guimaraes Rocha; André Anjos da Silva; Paulo Ricardo Assis de Souza; Artur Hartmann Hilgert; Camila Pocharski Barbosa; Caroline Grasso Kauppinem; Daniela Fernandes Martins; Daniela Silva Santos; Gabriel Henrique Colpes; Gabriela Ecco; Helena Margot Flores Soares da Silva; Louise Piva Penteado; Tatiane Dos Santos Journal: Genet Mol Biol Date: 2019-04-11 Impact factor: 1.771