OBJECTIVE: To identify the predictive factors (with emphasis on diagnostic delay) associated with the diagnosis of an advanced-clinical stage head and neck cancer. DESIGN: Cross-sectional study of patients with head and neck cancer originally recruited for a case-control study. SETTING: Three referral oncological centers in metropolitan areas in southern Brazil: São Paulo, Curitiba, and Goiânia. PATIENTS: The study population comprised 679 patients recently diagnosed as having a previously untreated head and neck squamous cell carcinoma. MAIN OUTCOME MEASURE: Diagnosis of advanced disease (clinical stage III-IV) head and neck cancer. RESULTS: Patients with laryngeal and hypopharyngeal cancers were more likely to be diagnosed as having advanced disease than those with lip, oral, and oropharyngeal cancers (88.0% vs 74.6%) (P<.001). Patient delay was inversely associated with clinical stage at diagnosis in patients with the same cancers, while professional delay was directly associated with a higher risk of advanced clinical stage at diagnosis (P =.001 and P =.006, respectively). In the analysis of laryngeal and hypopharyngeal cancer, both patient and professional delays were associated with advanced disease, with patient delay being a stronger predictive factor than professional delay. CONCLUSIONS: Clinical stage at diagnosis was associated with sociodemographic characteristics, patient delay, and professional delay. Our results indicate that continued educational programs for the population and health care professionals regarding the identification of early symptoms of head and neck cancers are warranted.
OBJECTIVE: To identify the predictive factors (with emphasis on diagnostic delay) associated with the diagnosis of an advanced-clinical stage head and neck cancer. DESIGN: Cross-sectional study of patients with head and neck cancer originally recruited for a case-control study. SETTING: Three referral oncological centers in metropolitan areas in southern Brazil: São Paulo, Curitiba, and Goiânia. PATIENTS: The study population comprised 679 patients recently diagnosed as having a previously untreated head and neck squamous cell carcinoma. MAIN OUTCOME MEASURE: Diagnosis of advanced disease (clinical stage III-IV) head and neck cancer. RESULTS:Patients with laryngeal and hypopharyngeal cancers were more likely to be diagnosed as having advanced disease than those with lip, oral, and oropharyngeal cancers (88.0% vs 74.6%) (P<.001). Patient delay was inversely associated with clinical stage at diagnosis in patients with the same cancers, while professional delay was directly associated with a higher risk of advanced clinical stage at diagnosis (P =.001 and P =.006, respectively). In the analysis of laryngeal and hypopharyngeal cancer, both patient and professional delays were associated with advanced disease, with patient delay being a stronger predictive factor than professional delay. CONCLUSIONS: Clinical stage at diagnosis was associated with sociodemographic characteristics, patient delay, and professional delay. Our results indicate that continued educational programs for the population and health care professionals regarding the identification of early symptoms of head and neck cancers are warranted.
Authors: Colin T Murphy; Thomas J Galloway; Elizabeth A Handorf; Brian L Egleston; Lora S Wang; Ranee Mehra; Douglas B Flieder; John A Ridge Journal: J Clin Oncol Date: 2015-11-30 Impact factor: 44.544
Authors: Ho-Sheng Lin; Harvinder S Talwar; Adi L Tarca; Alexei Ionan; Madhumita Chatterjee; Bin Ye; Jerzy Wojciechowski; Saroj Mohapatra; Marc D Basson; George H Yoo; Brian Peshek; Fulvio Lonardo; Chuan-Ju G Pan; Adam J Folbe; Sorin Draghici; Judith Abrams; Michael A Tainsky Journal: Cancer Epidemiol Biomarkers Prev Date: 2007-11 Impact factor: 4.254
Authors: Yuxuan Wang; Simeon Springer; Carolyn L Mulvey; Natalie Silliman; Joy Schaefer; Mark Sausen; Nathan James; Eleni M Rettig; Theresa Guo; Curtis R Pickering; Justin A Bishop; Christine H Chung; Joseph A Califano; David W Eisele; Carole Fakhry; Christine G Gourin; Patrick K Ha; Hyunseok Kang; Ana Kiess; Wayne M Koch; Jeffrey N Myers; Harry Quon; Jeremy D Richmon; David Sidransky; Ralph P Tufano; William H Westra; Chetan Bettegowda; Luis A Diaz; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Nishant Agrawal Journal: Sci Transl Med Date: 2015-06-24 Impact factor: 17.956
Authors: Ravindra Taware; Khushman Taunk; Jorge A M Pereira; Amey Shirolkar; Dharmesh Soneji; José S Câmara; H A Nagarajaram; Srikanth Rapole Journal: Sci Rep Date: 2018-12-07 Impact factor: 4.379