Literature DB >> 11886266

An antibody that prevents the hemagglutinin low pH fusogenic transition.

C Barbey-Martin1, B Gigant, T Bizebard, L J Calder, S A Wharton, J J Skehel, M Knossow.   

Abstract

We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition. (C)2002 Elsevier Science (USA).

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Year:  2002        PMID： 11886266     DOI： 10.1006/viro.2001.1320

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  81 in total

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