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Literature DB >> 11885597

NHEJ deficiency and disease.

Abstract

In mouse and human, diseases associated with deficiency of DNA ligase IV, a protein involved in DNA double-strand break repair, have been identified. Manifestation of some of these disease phenotypes, namely tumorigenesis, may require additional checkpoint deficiencies.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2001 PMID： 11885597 DOI： 10.1016/s1097-2765(01)00424-5

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

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Cited

12 in total

1. Effect of rad50 mutation on illegitimate recombination in Saccharomyces cerevisiae.

Authors: Cecilia Y Chan; Jie Zhu; Robert H Schiestl
Journal: Mol Genet Genomics Date: 2011-04-22 Impact factor: 3.291

2. Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs.

Authors: Jasminka Boskovic; Angel Rivera-Calzada; Joseph D Maman; Pablo Chacón; Keith R Willison; Laurence H Pearl; Oscar Llorca
Journal: EMBO J Date: 2003-11-03 Impact factor: 11.598

3. Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining.

Authors: Kihoon Lee; Sang Eun Lee
Journal: Genetics Date: 2007-06-11 Impact factor: 4.562

4. Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.

Authors: Joanna Trojanek; Thu Ho; Luis Del Valle; Michal Nowicki; Jin Ying Wang; Adam Lassak; Francesca Peruzzi; Kamel Khalili; Tomasz Skorski; Krzysztof Reiss
Journal: Mol Cell Biol Date: 2003-11 Impact factor: 4.272

5. Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.

Authors: Chen Wang; Huanyin Tang; Anke Geng; Binghua Dai; Haiping Zhang; Xiaoxiang Sun; Yu Chen; Zhibing Qiao; Hong Zhu; Jiamei Yang; Jiayu Chen; Qizhi He; Nan Qin; Jinru Xie; Rong Tan; Xiaoping Wan; Shaorong Gao; Ying Jiang; Fang-Lin Sun; Zhiyong Mao
Journal: Proc Natl Acad Sci U S A Date: 2020-10-05 Impact factor: 11.205

6. Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma.

Authors: Katarzyna Urbanska; Paola Pannizzo; Adam Lassak; Elisa Gualco; Eva Surmacz; Sidney Croul; Luis Del Valle; Kamel Khalili; Krzysztof Reiss
Journal: J Cell Physiol Date: 2009-05 Impact factor: 6.384

NHEJ deficiency and disease.

1. Effect of rad50 mutation on illegitimate recombination in Saccharomyces cerevisiae.

2. Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs.

3. Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining.

4. Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.

5. Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.

6. Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma.

7. Relevance of LIG4 gene polymorphisms with cancer susceptibility: evidence from a meta-analysis.

8. Deregulation of DNA double-strand break repair in multiple myeloma: implications for genome stability.

Review 9. IGF-IR in neuroprotection and brain tumors.

10. Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability.