Literature DB >> 11884756

Mannose receptor-mediated regulation of serum glycoprotein homeostasis.

Sena J Lee1, Stefan Evers, Daniel Roeder, Albert F Parlow, Juha Risteli, Leila Risteli, Y C Lee, Ten Feizi, Hanno Langen, Michel C Nussenzweig.   

Abstract

Carbohydrates are thought to function as tags that mark circulatory glycoproteins for rapid clearance. To examine the role of the mannose receptor (MR) in glycoprotein clearance, we generated mice genetically deficient in MR. MR-/- mice were defective in clearing proteins bearing accessible mannose and N-acetylglucosamine residues and had elevated levels of eight different lysosomal hydrolases. Proteomic analysis of MR-/- and control mouse sera showed that an additional 4 out of 52 proteins identified were elevated in MR-/- serum. Each of these is up-regulated during inflammation and wound healing. Thus, MR appears to operate as an essential regulator of serum glycoprotein homeostasis.

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Year:  2002        PMID： 11884756     DOI： 10.1126/science.1069540

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  181 in total

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