| Literature DB >> 11883931 |
Paula Stein1, Petr Svoboda, Deborah J Stumpo, Perry J Blackshear, David B Lombard, Brad Johnson, Richard M Schultz.
Abstract
The identity of mammalian genes involved in RNA interference (RNAi), the targeted sequence-specific mRNA degradation by double-stranded RNA (dsRNA), is poorly defined. Here we report the analysis of mice with null mutations of Wrn, Blm, and RecQ1 genes that are related to Mut-7 and Qde3, two genes essential for RNAi in Caenorhabditis elegans and quelling in Neurospora, respectively. Our results suggest that Wrn, Blm, and RecQ1 are not involved in sequence-specific mRNA degradation in mammals in response to dsRNA, suggesting potential differences in the mammalian RNAi pathway. (C)2002 Elsevier Science (USA).Entities:
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Year: 2002 PMID： 11883931 DOI： 10.1006/bbrc.2002.6578
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575