Testosterone increased blood pressure and decreased renal tyrosine hydroxylase activity in SHR/y and Wistar-Kyoto rats.

The present study evaluated the association between a testosterone-induced elevation in blood pressure (BP) and renal tyrosine hydroxylase activity in SHR/y and Wistar-Kyoto male rats. The SHR/y rat is a consomic strain having the Y chromosome of the Spontaneously Hypertensive Rat and autosomes and the X chromosome from normotensive Wistar-Kyoto (WKY). Rats were castrated at 4-6 weeks and divided into control and sham groups (n = 6/group) with testosterone and blank sham implants respectively. BP and blood were taken every 2 weeks for estimation of serum testosterone and catecholamines. The animals were terminated at 16-18 weeks and kidneys were removed for the estimation of tyrosine hydroxylase activity. The testosterone treated rats had higher BP, plasma testosterone levels, kidney weights, but lower renal tyrosine hydroxylase activity than the sham treated controls. Hence, chronic testosterone treatment inhibits renal tyrosine hydroxylase activity in WKY and SHR/y rats.