Literature DB >> 11883693

Recombinant yeast as a vaccine vector for the induction of cytotoxic T-lymphocyte responses.

Andrew C Stubbs1, Cara C Wilson.   

Abstract

There is currently a need to develop safe and effective vaccines for the induction of cellular, in particular cytotoxic T-lymphocyte-mediated, protective immune responses. This review focuses on the challenges presented by such an endeavor, current strategies for the induction of such responses, and the relatively new idea that recombinant yeast may represent an ideal vaccine vector for the induction of cellular immune responses.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11883693

Source DB:  PubMed          Journal:  Curr Opin Mol Ther        ISSN： 1464-8431


  5 in total

1.  Vaccination with a recombinant Saccharomyces cerevisiae expressing a tumor antigen breaks immune tolerance and elicits therapeutic antitumor responses.

Authors:  Elizabeth K Wansley; Mala Chakraborty; Kenneth W Hance; Michael B Bernstein; Amanda L Boehm; Zhimin Guo; Deborah Quick; Alex Franzusoff; John W Greiner; Jeffrey Schlom; James W Hodge
Journal:  Clin Cancer Res       Date:  2008-07-01       Impact factor: 12.531

Review 2.  Vaccines based on whole recombinant Saccharomyces cerevisiae cells.

Authors:  Andressa Ardiani; Jack P Higgins; James W Hodge
Journal:  FEMS Yeast Res       Date:  2010-12       Impact factor: 2.796

3.  Phase I trial of a recombinant yeast-CEA vaccine (GI-6207) in adults with metastatic CEA-expressing carcinoma.

Authors:  Marijo Bilusic; Christopher R Heery; Philip M Arlen; Myrna Rauckhorst; David Apelian; Kwong Y Tsang; Jo A Tucker; Caroline Jochems; Jeffrey Schlom; James L Gulley; Ravi A Madan
Journal:  Cancer Immunol Immunother       Date:  2013-12-07       Impact factor: 6.968

4.  Randomized, Double-Blind, Placebo-Controlled Phase II Study of Yeast-Brachyury Vaccine (GI-6301) in Combination with Standard-of-Care Radiotherapy in Locally Advanced, Unresectable Chordoma.

Authors:  Peter Joseph DeMaria; Marijo Bilusic; Deric M Park; Christopher R Heery; Renee N Donahue; Ravi A Madan; Mohammad Hadi Bagheri; Julius Strauss; Victoria Shen; Jennifer L Marté; Seth M Steinberg; Jeffrey Schlom; Mark R Gilbert; James L Gulley
Journal:  Oncologist       Date:  2021-03-09

5.  In vivo phage display to identify M cell-targeting ligands.

Authors:  Lisa M Higgins; Imelda Lambkin; Graham Donnelly; Daragh Byrne; Carolyn Wilson; Jacqueline Dee; Melanie Smith; Daniel J O'Mahony
Journal:  Pharm Res       Date:  2004-04       Impact factor: 4.580
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.