Literature DB >> 11882008

Synthesis and antimycobacterial activity of 6-arylpurines: the requirements for the N-9 substituent in active antimycobacterial purines.

Lise-Lotte Gundersen1, Jon Nissen-Meyer, Bjørn Spilsberg.   

Abstract

6-Arylpurines carrying a variety of substituents in the 9-position were prepared by Stille coupling between appropriately substituted 6-chloropurines and aryl(tributyl)tin, and the compounds were screened for antibacterial activity against Mycobacterium tuberculosis H(37)Rv. The lowest minimum inhibitory concentration value, 0.78 microg/mL, was found for 9-benzyl-2-chloro-6-(2-furyl)purine. This compound exhibited relatively low cytotoxicity, and it was active against several singly drug-resistant strains of M. tuberculosis.

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Year:  2002        PMID： 11882008     DOI： 10.1021/jm0110284

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  7 in total

1.  6-Oxo and 6-thio purine analogs as antimycobacterial agents.

Authors:  Ashish K Pathak; Vibha Pathak; Lainne E Seitz; William J Suling; Robert C Reynolds
Journal:  Bioorg Med Chem       Date:  2013-02-04       Impact factor: 3.641

2.  Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides.

Authors:  Abdalla E A Hassan; Reham A I Abou-Elkhair; James M Riordan; Paula W Allan; William B Parker; Rashmi Khare; William R Waud; John A Montgomery; John A Secrist
Journal:  Eur J Med Chem       Date:  2011-11-04       Impact factor: 6.514

Review 3.  New small-molecule synthetic antimycobacterials.

Authors:  Lluis Ballell; Robert A Field; Ken Duncan; Robert J Young
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191

Review 4.  Synthesis and structural activity relationship study of antitubercular carboxamides.

Authors:  D I Ugwu; B E Ezema; F U Eze; D I Ugwuja
Journal:  Int J Med Chem       Date:  2014-12-30

5.  Green Synthesis of Oxoquinoline-1(2H)-Carboxamide as Antiproliferative and Antioxidant Agents: An Experimental and In-Silico Approach to High Altitude Related Disorders.

Authors:  Amena Ali; Abuzer Ali; Musarrat Husain Warsi; Mohammad Akhlaquer Rahman; Mohamed Jawed Ahsan; Faizul Azam
Journal:  Molecules       Date:  2022-01-04       Impact factor: 4.411

6.  Synthesis, Antimicrobial and cytotoxic activity of New Heterocyclic Hybrids Based on 2,5-Dimethylpyrrole and Pyrrole Scaffolds.

Authors:  S D Joshi; U A More; V H Kulkarni
Journal:  Indian J Pharm Sci       Date:  2013-05       Impact factor: 0.975

7.  Versatile synthesis and biological evaluation of novel 3'-fluorinated purine nucleosides.

Authors:  Hang Ren; Haoyun An; Paul J Hatala; William C Stevens; Jingchao Tao; Baicheng He
Journal:  Beilstein J Org Chem       Date:  2015-12-09       Impact factor: 2.883
  7 in total

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