STUDY DESIGN: The efficacy of intrathecal (spinal) morphine in the treatment of pain after posterior spinal fusions was assessed. OBJECTIVE: To investigate improved posterior pain control with fewer side effects in patients with posterior spinal fusions. SUMMARY OF BACKGROUND DATA: After multilevel spinal fusion with instrumentation, patients experience considerable pain that is difficult to treat. METHODS: For this study, 65 patients undergoing elective multilevel posterior spinal instrumentation were randomized to receive spinal morphine as follows: 10 microgram/kg, 20 microgram/kg, or none. These patients were assessed after surgery for pain control and narcotic-associated complications. RESULTS: The patients who received 20 microgram/kg of spinal morphine were more comfortable immediately after surgery, remained pain free for a longer period, and required significantly less additional narcotic. These patients also had fewer respiratory complications. CONCLUSIONS: Relatively high-dose spinal morphine administration provides simple, reliable postoperative pain control after posterior spinal fusions. This may contribute to reduced postoperative respiratory morbidity and an improved outcome.
RCT Entities:
STUDY DESIGN: The efficacy of intrathecal (spinal) morphine in the treatment of pain after posterior spinal fusions was assessed. OBJECTIVE: To investigate improved posterior pain control with fewer side effects in patients with posterior spinal fusions. SUMMARY OF BACKGROUND DATA: After multilevel spinal fusion with instrumentation, patients experience considerable pain that is difficult to treat. METHODS: For this study, 65 patients undergoing elective multilevel posterior spinal instrumentation were randomized to receive spinal morphine as follows: 10 microgram/kg, 20 microgram/kg, or none. These patients were assessed after surgery for pain control and narcotic-associated complications. RESULTS: The patients who received 20 microgram/kg of spinal morphine were more comfortable immediately after surgery, remained pain free for a longer period, and required significantly less additional narcotic. These patients also had fewer respiratory complications. CONCLUSIONS: Relatively high-dose spinal morphine administration provides simple, reliable postoperative pain control after posterior spinal fusions. This may contribute to reduced postoperative respiratory morbidity and an improved outcome.
Authors: Arif Pendi; Yu-Po Lee; Saif Al-Deen B Farhan; Frank L Acosta; S Samuel Bederman; Ronald Sahyouni; Elias R Gerrick; Nitin N Bhatia Journal: J Spine Surg Date: 2018-06
Authors: Mandy Mj Li; Don Daniel Ocay; Alisson R Teles; Pablo M Ingelmo; Jean A Ouellet; M Gabrielle Pagé; Catherine E Ferland Journal: J Pain Res Date: 2019-05-23 Impact factor: 3.133
Authors: Carlos Alexandre Botelho do Amaral; Tertuliano Vieira; Edgar Taira Nakagawa; Eduardo Aires Losch; Pedro José Labronici Journal: Rev Bras Ortop Date: 2015-02-19