BACKGROUND: Accidental contamination with polybrominated biphenyls (PBBs) of the Michigan food supply in 1973 led to the exposure of more than 4000 individuals and to formation of the PBB cohort registry (1976-1979). At enrollment, measurements were taken of serum PBB and polychlorinated biphenyl (PCB), possible endocrine disrupting chemicals. METHODS: We examined the association of estimated PBB and PCB exposure during pregnancy with current height and weight in 308 daughters, 5-24 years of age (mean age 15.2 years), born to women in the cohort. We estimated prenatal PBB exposure using maternal enrollment serum PBB and a model of PBB elimination. Prenatal PCB exposure was estimated using maternal enrollment serum PCB because background-level exposure through diet was ongoing. Self-reported height and weight were obtained from a 1997-1998 health survey. RESULTS: We found no association between prenatal PBB exposure and either daughter's current height or daughter's weight adjusted for height; however, prenatal PCB exposure above 5 parts per billion was associated with reduced weight adjusted for height. Exposure through breastfeeding did not modify the association. CONCLUSIONS: Mothers with PCB levels above the median had daughters whose current weights were 11 pounds lower than that of the daughters whose mothers had levels below the median. This study provides evidence that prenatal exposure to PCBs may affect growth.
BACKGROUND: Accidental contamination with polybrominated biphenyls (PBBs) of the Michigan food supply in 1973 led to the exposure of more than 4000 individuals and to formation of the PBB cohort registry (1976-1979). At enrollment, measurements were taken of serum PBB and polychlorinated biphenyl (PCB), possible endocrine disrupting chemicals. METHODS: We examined the association of estimated PBB and PCB exposure during pregnancy with current height and weight in 308 daughters, 5-24 years of age (mean age 15.2 years), born to women in the cohort. We estimated prenatal PBB exposure using maternal enrollment serum PBB and a model of PBB elimination. Prenatal PCB exposure was estimated using maternal enrollment serum PCB because background-level exposure through diet was ongoing. Self-reported height and weight were obtained from a 1997-1998 health survey. RESULTS: We found no association between prenatal PBB exposure and either daughter's current height or daughter's weight adjusted for height; however, prenatal PCB exposure above 5 parts per billion was associated with reduced weight adjusted for height. Exposure through breastfeeding did not modify the association. CONCLUSIONS: Mothers with PCB levels above the median had daughters whose current weights were 11 pounds lower than that of the daughters whose mothers had levels below the median. This study provides evidence that prenatal exposure to PCBs may affect growth.
Authors: Jordan T Perkins; Michael C Petriello; Bradley J Newsome; Bernhard Hennig Journal: Environ Sci Pollut Res Int Date: 2015-04-17 Impact factor: 4.223
Authors: Jane S Burns; Paige L Williams; Oleg Sergeyev; Susan Korrick; Mary M Lee; Boris Revich; Larisa Altshul; Julie T Del Prato; Olivier Humblet; Donald G Patterson; Wayman E Turner; Larry L Needham; Mikhail Starovoytov; Russ Hauser Journal: Pediatrics Date: 2010-12-27 Impact factor: 7.124
Authors: Renée Dallaire; Éric Dewailly; Pierre Ayotte; Nadine Forget-Dubois; Sandra W Jacobson; Joseph L Jacobson; Gina Muckle Journal: Environ Res Date: 2014-07-18 Impact factor: 6.498
Authors: Kathleen A Wannemuehler; Robert H Lyles; Amita K Manatunga; Metrecia L Terrell; Michele Marcus Journal: Stat Med Date: 2010-07-20 Impact factor: 2.373
Authors: Jeanett L Tang-Péronard; Berit L Heitmann; Helle R Andersen; Ulrike Steuerwald; Philippe Grandjean; Pál Weihe; Tina K Jensen Journal: Am J Clin Nutr Date: 2013-10-23 Impact factor: 7.045
Authors: Nancy A Mervish; Eliza W Gardiner; Maida P Galvez; Larry H Kushi; Gayle C Windham; Frank M Biro; Susan M Pinney; Michael E Rybak; Susan L Teitelbaum; Mary S Wolff Journal: Nutr Res Date: 2013-05-31 Impact factor: 3.315