Literature DB >> 11880232

Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine.

N Sriwilaijareon1, S Petmitr, A Mutirangura, M Ponglikitmongkol, P Wilairat.   

Abstract

Telomerase activity in synchronized Plasmodium falciparum during its erythrocytic cycle was examined using the TRAP assay. Telomerase activity was detected at all stages of the parasite intraerythrocyte development, with higher activity in trophozoite and schizont stages compared with ring form. Berberine, extracted from Arcangelisia flava (L.) Merr., inhibited telomerase activity in a dose-dependent manner over a range of 30-300 microM, indicating that P. falciparum telomerase might be a potential target for future malaria chemotherapy.

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Year:  2002        PMID： 11880232     DOI： 10.1016/s1383-5769(01)00092-7

Source DB:  PubMed          Journal:  Parasitol Int        ISSN： 1383-5769            Impact factor:   2.230


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