| Literature DB >> 11880053 |
Abstract
Recent studies in transgenic mice confirmed that C-reactive protein is protective against microbial pathogens. This is consistent with its ability in vitro to bind microbes, activate the complement classical pathway, and engage FcgammaRI and FcgammaRII. However, in transgenic mice protection also requires the alternative pathway of complement, and FcgammaRI is dispensable.Entities:
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Year: 2002 PMID: 11880053 DOI: 10.1016/s1286-4579(01)01528-3
Source DB: PubMed Journal: Microbes Infect ISSN: 1286-4579 Impact factor: 2.700