Literature DB >> 11879771

Medicinal chemistry and therapeutic potential of CpG DNA.

Sudhir Agrawal1, Ekambar R Kandimalla.   

Abstract

The observation that oligodeoxynucleotides containing CpG dinucleotides (CpG DNA) exhibit several immunological effects has led to their use as therapeutic agents and adjuvants for various diseases. Several CpG DNA drug candidates are currently being evaluated, either as monotherapies or as adjuvants (with vaccines, antibodies, antigens and allergens), in preclinical and clinical trials against cancers, viral and bacterial infections, allergies and asthma. Knowledge gained from studies of the medicinal chemistry of CpG DNA has provided a basis for designing a second generation of CpG DNA agents with desirable cytokine-inducing and potent immunomodulatory activity. This article reviews recent progress in understanding the effects of CpG DNA, the medicinal chemistry of CpG DNA, and its possible therapeutic applications.

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Year:  2002        PMID： 11879771     DOI： 10.1016/s1471-4914(01)02264-x

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  12 in total

1.  'Immunomers'--novel 3'-3'-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents.

Authors:  Dong Yu; Ekambar R Kandimalla; Lakshmi Bhagat; Jin-Yan Tang; Yanping Cong; Jimmy Tang; Sudhir Agrawal
Journal:  Nucleic Acids Res       Date:  2002-10-15       Impact factor: 16.971

2.  Impact of site-specific nucleobase deletions on the arthritogenicity of DNA.

Authors:  Jan L Bjersing; Andrej Tarkowski; Ekambar R Kandimalla; Helen Karlsson; Sudhir Agrawal; L Vincent Collins
Journal:  Inflammation       Date:  2004-06       Impact factor: 4.092

3.  CpG-oligodeoxynucleotide is a potent adjuvant with an Entamoeba histolytica Gal-inhibitable lectin vaccine against amoebic liver abscess in gerbils.

Authors:  Catherine P A Ivory; Kathy Keller; Kris Chadee
Journal:  Infect Immun       Date:  2006-01       Impact factor: 3.441

4.  The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept).

Authors:  Valentina Taverniti; Simone Guglielmetti
Journal:  Genes Nutr       Date:  2011-04-16       Impact factor: 5.523

5.  CpG oligodeoxynucleotides promote the host protective response against infection with Cryptococcus neoformans through induction of interferon-gamma production by CD4+ T cells.

Authors:  K Miyagi; K Kawakami; Y Kinjo; K Uezu; T Kinjo; K Nakamura; A Saito
Journal:  Clin Exp Immunol       Date:  2005-05       Impact factor: 4.330

6.  Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment.

Authors:  Xin Liu; Xinchuan Zheng; Ning Wang; Hongwei Cao; Yongling Lu; Yupeng Long; Kecen Zhao; Hong Zhou; Jiang Zheng
Journal:  Br J Pharmacol       Date:  2011-03       Impact factor: 8.739

7.  Structure-dependent modulation of alpha interferon production by porcine circovirus 2 oligodeoxyribonucleotide and CpG DNAs in porcine peripheral blood mononuclear cells.

Authors:  Frida Hasslung Wikström; Brian M Meehan; Mikael Berg; Sirje Timmusk; Josefine Elving; Lisbeth Fuxler; Mattias Magnusson; Gordon M Allan; Francis McNeilly; Caroline Fossum
Journal:  J Virol       Date:  2007-02-28       Impact factor: 5.103

8.  Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles.

Authors:  Ekambar R Kandimalla; Lakshmi Bhagat; Daqing Wang; Dong Yu; Fu-Gang Zhu; Jimmy Tang; Hui Wang; Ping Huang; Ruiwen Zhang; Sudhir Agrawal
Journal:  Nucleic Acids Res       Date:  2003-05-01       Impact factor: 16.971

9.  Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid dendritic cells.

Authors:  Kristina Abel; Yichuan Wang; Linda Fritts; Eleonora Sanchez; Eugene Chung; Patricia Fitzgerald-Bocarsly; Arthur M Krieg; Christopher J Miller
Journal:  Clin Diagn Lab Immunol       Date:  2005-05

10.  A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif.

Authors:  Ekambar R Kandimalla; Lakshmi Bhagat; Fu-Gang Zhu; Dong Yu; Yan-Ping Cong; Daqing Wang; Jimmy X Tang; Jin-Yan Tang; Cathrine F Knetter; Egil Lien; Sudhir Agrawal
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-10       Impact factor: 11.205
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