Mechanical ventilation and renal function: an area for concern?

Mechanical ventilation is a standard component of intensive care unit management of critically ill patients and widely used for respiratory support. Patients requiring ventilation often have renal dysfunction that can occur as a consequence of the underlying disease or be related to the therapy. Although the physiological consequences of mechanical ventilation on pulmonary and cardiovascular function have been extensively studied, its effects on renal function are not as well defined. Previous experimental studies and few clinical reports have shown a significant effect of mechanical ventilation on renal function. This review compiles the information in this area and provides a framework for future investigation in this field. Copyright 2002 by the National Kidney Foundation, Inc.