BACKGROUND: Platelets have been suggested to play a role in the early development of atherosclerosis. As one test of this hypothesis, we assessed whether patients with Glanzmann thrombasthenia who lack platelet glycoprotein alpha(IIb)beta(3) (GPIIb/IIIa) complexes or both alpha(IIb)beta(3) and the more ubiquitous alpha(v)beta(3) cell membrane complexes are protected from development of atherosclerosis. METHODS AND RESULTS: Seven patients with Glanzmann thrombasthenia, 45 to 66 years of age, underwent bilateral carotid artery ultrasonography and screening for risk factors of atherosclerosis. Findings consistent with early atherosclerosis evaluated by measurement of intima-media thickness and presence of atherosclerotic plaques were observed in 6 of the 7 patients. Intima-media thickness values higher than the 75th and 90th percentiles of age- and sex-matched white control subjects of the Atherosclerosis Risk in Communities (ARIC) study were observed in 30 and 8 of 56 carotid artery measurements, respectively. Five of the 6 patients with signs consistent with early atherosclerosis lacked both alpha(IIb)beta(3) and alpha(v)beta(3) complexes and 1 only lacked alpha(IIb)beta(3). CONCLUSIONS: Glanzmann thrombasthenia does not protect affected individuals from development of atherosclerosis.
BACKGROUND: Platelets have been suggested to play a role in the early development of atherosclerosis. As one test of this hypothesis, we assessed whether patients with Glanzmann thrombasthenia who lack platelet glycoprotein alpha(IIb)beta(3) (GPIIb/IIIa) complexes or both alpha(IIb)beta(3) and the more ubiquitous alpha(v)beta(3) cell membrane complexes are protected from development of atherosclerosis. METHODS AND RESULTS: Seven patients with Glanzmann thrombasthenia, 45 to 66 years of age, underwent bilateral carotid artery ultrasonography and screening for risk factors of atherosclerosis. Findings consistent with early atherosclerosis evaluated by measurement of intima-media thickness and presence of atherosclerotic plaques were observed in 6 of the 7 patients. Intima-media thickness values higher than the 75th and 90th percentiles of age- and sex-matched white control subjects of the Atherosclerosis Risk in Communities (ARIC) study were observed in 30 and 8 of 56 carotid artery measurements, respectively. Five of the 6 patients with signs consistent with early atherosclerosis lacked both alpha(IIb)beta(3) and alpha(v)beta(3) complexes and 1 only lacked alpha(IIb)beta(3). CONCLUSIONS:Glanzmann thrombasthenia does not protect affected individuals from development of atherosclerosis.
Authors: Sherry Weng; Laura Zemany; Kara N Standley; Deborah V Novack; Marie La Regina; Carlos Bernal-Mizrachi; Trey Coleman; Clay F Semenkovich Journal: Proc Natl Acad Sci U S A Date: 2003-05-13 Impact factor: 11.205
Authors: Peter Kraft; Christiane Drechsler; Ignaz Gunreben; Peter Ulrich Heuschmann; Christoph Kleinschnitz Journal: PLoS One Date: 2015-03-06 Impact factor: 3.240
Authors: Francesco Paciullo; Loredana Bury; Patrizia Noris; Emanuela Falcinelli; Federica Melazzini; Sara Orsini; Carlo Zaninetti; Rezan Abdul-Kadir; Deborah Obeng-Tuudah; Paula G Heller; Ana C Glembotsky; Fabrizio Fabris; Jose Rivera; Maria Luisa Lozano; Nora Butta; Remi Favier; Ana Rosa Cid; Marc Fouassier; Gian Marco Podda; Cristina Santoro; Elvira Grandone; Yvonne Henskens; Paquita Nurden; Barbara Zieger; Adam Cuker; Katrien Devreese; Alberto Tosetto; Erica De Candia; Arnaud Dupuis; Koji Miyazaki; Maha Othman; Paolo Gresele Journal: Haematologica Date: 2019-09-26 Impact factor: 9.941