Literature DB >> 11875518

Solution structure of the DNA-binding domain of MafG.

Hideki Kusunoki1, Hozumi Motohashi, Fumiki Katsuoka, Akio Morohashi, Masayuki Yamamoto, Toshiyuki Tanaka.   

Abstract

The Maf family proteins, which constitute a subgroup of basic region-leucine zipper (bZIP) proteins, function as transcriptional regulators of cellular differentiation. Together with the basic region, the Maf extended homology region (EHR), conserved only within the Maf family, defines the DNA binding specific to Mafs. Here we present the first NMR-derived structure of the DNA-binding domain (residues 1-76) of MafG, which contains the EHR and the basic region. The structure consists of three alpha-helices and resembles the fold of the DNA-binding domain of Skn-1, a developmental transcription factor of Caenorhabditis elegans. The structural similarity between MafG and Skn-1 enables us to propose a possible mechanism by which Maf family proteins recognize their consensus DNA sequences.

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Year:  2002        PMID： 11875518     DOI： 10.1038/nsb771

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  12 in total

1.  Synergistic transcription activation by Maf and Sox and their subnuclear localization are disrupted by a mutation in Maf that causes cataract.

Authors:  Nirmala Rajaram; Tom K Kerppola
Journal:  Mol Cell Biol       Date:  2004-07       Impact factor: 4.272

2.  Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.

Authors:  Yongyong Hou; Peng Xue; Yushi Bai; Dianxin Liu; Courtney G Woods; Kathy Yarborough; Jingqi Fu; Qiang Zhang; Guifan Sun; Sheila Collins; Jefferson Y Chan; Masayuki Yamamoto; Melvin E Andersen; Jingbo Pi
Journal:  Free Radic Biol Med       Date:  2011-10-28       Impact factor: 7.376

3.  Pi class glutathione S-transferase genes are regulated by Nrf 2 through an evolutionarily conserved regulatory element in zebrafish.

Authors:  Takafumi Suzuki; Yaeko Takagi; Hitoshi Osanai; Li Li; Miki Takeuchi; Yasutake Katoh; Makoto Kobayashi; Masayuki Yamamoto
Journal:  Biochem J       Date:  2005-05-15       Impact factor: 3.857

4.  MafG sumoylation is required for active transcriptional repression.

Authors:  Hozumi Motohashi; Fumiki Katsuoka; Chika Miyoshi; Yasuhiro Uchimura; Hisato Saitoh; Claire Francastel; James Douglas Engel; Masayuki Yamamoto
Journal:  Mol Cell Biol       Date:  2006-06       Impact factor: 4.272

Review 5.  Small Maf proteins (MafF, MafG, MafK): History, structure and function.

Authors:  Fumiki Katsuoka; Masayuki Yamamoto
Journal:  Gene       Date:  2016-04-05       Impact factor: 3.688

6.  Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes.

Authors:  Fumiki Katsuoka; Hozumi Motohashi; Tetsuro Ishii; Hiroyuki Aburatani; James Douglas Engel; Masayuki Yamamoto
Journal:  Mol Cell Biol       Date:  2005-09       Impact factor: 4.272

7.  Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway.

Authors:  Hozumi Motohashi; Fumiki Katsuoka; James Douglas Engel; Masayuki Yamamoto
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-15       Impact factor: 11.205

Review 8.  The importance of being flexible: the case of basic region leucine zipper transcriptional regulators.

Authors:  Maria Miller
Journal:  Curr Protein Pept Sci       Date:  2009-06       Impact factor: 3.272

9.  The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation.

Authors:  Debanu Das; Nick V Grishin; Abhinav Kumar; Dennis Carlton; Constantina Bakolitsa; Mitchell D Miller; Polat Abdubek; Tamara Astakhova; Herbert L Axelrod; Prasad Burra; Connie Chen; Hsiu Ju Chiu; Michelle Chiu; Thomas Clayton; Marc C Deller; Lian Duan; Kyle Ellrott; Dustin Ernst; Carol L Farr; Julie Feuerhelm; Anna Grzechnik; Slawomir K Grzechnik; Joanna C Grant; Gye Won Han; Lukasz Jaroszewski; Kevin K Jin; Hope A Johnson; Heath E Klock; Mark W Knuth; Piotr Kozbial; S Sri Krishna; David Marciano; Daniel McMullan; Andrew T Morse; Edward Nigoghossian; Amanda Nopakun; Linda Okach; Silvya Oommachen; Jessica Paulsen; Christina Puckett; Ron Reyes; Christopher L Rife; Natasha Sefcovic; Henry J Tien; Christine B Trame; Henry van den Bedem; Dana Weekes; Tiffany Wooten; Qingping Xu; Keith O Hodgson; John Wooley; Marc André Elsliger; Ashley M Deacon; Adam Godzik; Scott A Lesley; Ian A Wilson
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-10-27

10.  Structural basis of alternative DNA recognition by Maf transcription factors.

Authors:  Hirofumi Kurokawa; Hozumi Motohashi; Shinji Sueno; Momoko Kimura; Hiroaki Takagawa; Yousuke Kanno; Masayuki Yamamoto; Toshiyuki Tanaka
Journal:  Mol Cell Biol       Date:  2009-09-21       Impact factor: 4.272
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