| Literature DB >> 11875462 |
C C Chang1, R Ciubotariu, J S Manavalan, J Yuan, A I Colovai, F Piazza, S Lederman, M Colonna, R Cortesini, R Dalla-Favera, N Suciu-Foca.
Abstract
Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells. We show here that CD8+CD28(-) alloantigen-specific T suppressor (TS) cells induce the up-regulation of ILT3 and ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and induce antigen-specific unresponsiveness in CD4+ T helper cells. Studies of human heart transplant recipients showed that rejection-free patients have circulating TS cells, which induce the up-regulation of ILT3 and ILT4 in donor APCs. These findings demonstrate an important mechanism of immune regulation.Entities:
Mesh：
Substances：
Year: 2002 PMID： 11875462 DOI： 10.1038/ni760
Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606