Literature DB >> 11874200

Inhibition of rat brain Na+, K+-ATPase activity induced by homocysteine is probably mediated by oxidative stress.

E L Streck1, A I Zugno, B Tagliari, R Franzon, C M Wannmacher, M Wajner, A T Wyse.   

Abstract

The objective of the present study was to investigate the effects of preincubation of hippocampus homogenates in the presence of homocysteine or methionine on Na+, K+-ATPase and Mg2+-ATPase activities in synaptic membranes of rats. Homocysteine significantly inhibited Na+, K+-ATPase activity, whereas methionine had no effect. Mg2+-ATPase activity was not altered by the metabolites. We also evaluated the effect of incubating glutathione, cysteine, dithiothreitol, trolox, superoxide dismutase and GM1 ganglioside alone or incubation with homocysteine on Na+, K+-ATPase activity. Tested compounds did not alter Na+, K+-ATPase and Mg2+-ATPase activities, but except for trolox, prevented the inhibitory effect of homocysteine on Na+, K+-ATPase activity. These results suggest that inhibition of this enzyme activity by homocysteine is possibly mediated by free radicals and may contribute to the neurological dysfunction found in homocystinuric patients.

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Year:  2001        PMID： 11874200     DOI： 10.1023/a:1013907104585

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  28 in total

1.  The effect of cyst(e)ine on the auto-oxidation of homocysteine.

Authors:  N Hogg
Journal:  Free Radic Biol Med       Date:  1999-07       Impact factor: 7.376

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Authors:  W K Kim; Y S Pae
Journal:  Neurosci Lett       Date:  1996-09-27       Impact factor: 3.046

3.  Biokinetics of dietary RRR-alpha-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not "spare" vitamin E in vivo.

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Journal:  Lipids       Date:  1990-04       Impact factor: 1.880

4.  Neurotoxicity at the N-methyl-D-aspartate receptor in energy-compromised neurons. An hypothesis for cell death in aging and disease.

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Journal:  Ann N Y Acad Sci       Date:  1989       Impact factor: 5.691

Review 5.  Homocysteine, oxidative stress, and vascular disease.

Authors:  G N Welch; G R Upchurch; J Loscalzo
Journal:  Hosp Pract (1995)       Date:  1997-06-15

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Journal:  Anal Biochem       Date:  1986-09       Impact factor: 3.365

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Journal:  Biochim Biophys Acta       Date:  1974-08-09

Review 8.  Contributory mechanisms in the causation of neurodegenerative disorders.

Authors:  G J Lees
Journal:  Neuroscience       Date:  1993-05       Impact factor: 3.590

9.  Effect of hyperbaric oxygenation on the Na+, K(+)-ATPase and membrane fluidity of cerebrocortical membranes after experimental subarachnoid hemorrhage.

Authors:  K Yufu; T Itoh; R Edamatsu; A Mori; M Hirakawa
Journal:  Neurochem Res       Date:  1993-09       Impact factor: 3.996

10.  Seizures induced by homocysteine in rats during ontogenesis.

Authors:  H Kubová; J Folbergrová; P Mares
Journal:  Epilepsia       Date:  1995-08       Impact factor: 5.864
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  23 in total

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Authors:  Graziela S Ribas; Angela Sitta; Moacir Wajner; Carmen R Vargas
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2.  Isolation stress during the prepubertal period in rats induces long-lasting neurochemical changes in the prefrontal cortex.

Authors:  R Krolow; C Noschang; S N Weis; L F Pettenuzzo; A P Huffell; D M Arcego; M Marcolin; C S Mota; J Kolling; E B S Scherer; A T S Wyse; C Dalmaz
Journal:  Neurochem Res       Date:  2012-02-11       Impact factor: 3.996

3.  Na+, K+ ATPase activity is reduced in amygdala of rats with chronic stress-induced anxiety-like behavior.

Authors:  Leonardo Crema; Michele Schlabitz; Bárbara Tagliari; Aline Cunha; Fabrício Simão; Rachel Krolow; Letícia Pettenuzzo; Christianne Salbego; Deusa Vendite; Angela T S Wyse; Carla Dalmaz
Journal:  Neurochem Res       Date:  2010-08-18       Impact factor: 3.996

4.  Neurochemical evidence that lysine inhibits synaptic Na+,K+-ATPase activity and provokes oxidative damage in striatum of young rats in vivo.

Authors:  Bianca Seminotti; Carolina Gonçalves Fernandes; Guilhian Leipnitz; Alexandre Umpierrez Amaral; Angela Zanatta; Moacir Wajner
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5.  The influence of early life interventions on olfactory memory related to palatable food, and on oxidative stress parameters and Na+/K+-ATPase activity in the hippocampus and olfactory bulb of female adult rats.

Authors:  Cristie Noschang; Rachel Krolow; Danusa M Arcego; Daniela Laureano; Luiza D Fitarelli; Ana Paula Huffell; Andréa G K Ferreira; Aline A da Cunha; Fernanda Rossato Machado; Angela T S Wyse; Carla Dalmaz
Journal:  Neurochem Res       Date:  2012-05-10       Impact factor: 3.996

6.  Alterations on Na⁺,K⁺-ATPase and acetylcholinesterase activities induced by amyloid-β peptide in rat brain and GM1 ganglioside neuroprotective action.

Authors:  Fernando Kreutz; Emilene B Scherer; Andréa G K Ferreira; Fernanda Dos Santos Petry; Camila Lino Pereira; Fabiana Santana; Angela Terezinha de Souza Wyse; Christianne Gazzana Salbego; Vera Maria Treis Trindade
Journal:  Neurochem Res       Date:  2013-09-08       Impact factor: 3.996

7.  Experimental evidence that phenylalanine provokes oxidative stress in hippocampus and cerebral cortex of developing rats.

Authors:  Carolina G Fernandes; Guilhian Leipnitz; Bianca Seminotti; Alexandre U Amaral; Angela Zanatta; Carmen R Vargas; Carlos S Dutra Filho; Moacir Wajner
Journal:  Cell Mol Neurobiol       Date:  2009-09-23       Impact factor: 5.046

8.  Profiling of oxidative stress in patients with inborn errors of metabolism.

Authors:  Peter J Mc Guire; Aditya Parikh; George A Diaz
Journal:  Mol Genet Metab       Date:  2009-06-14       Impact factor: 4.797

9.  Homocysteine inhibits butyrylcholinesterase activity in rat serum.

Authors:  Francieli M Stefanello; Alexandra I Zugno; Clovis M D Wannmacher; Moacir Wajner; Angela T S Wyse
Journal:  Metab Brain Dis       Date:  2003-09       Impact factor: 3.584

10.  Contextual fear conditioning in maternal separated rats: the amygdala as a site for alterations.

Authors:  Luisa A Diehl; Natividade de Sá Couto Pereira; Daniela P Laureano; André N D Benitz; Cristie Noschang; Andrea G K Ferreira; Emilene B Scherer; Fernanda R Machado; Thiago Pereira Henriques; Angela T S Wyse; Victor Molina; Carla Dalmaz
Journal:  Neurochem Res       Date:  2013-12-25       Impact factor: 3.996
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