Joachim Volz1, Udo Heinrich, Stefanie Volz-Köster. 1. Department of Gynecology and Obstetrics, University Hospital Mannheim, Mannheim, Germany. joachim.volz@gyn.ma.uni-heidelberg.de
Abstract
OBJECTIVE: To report the first case of pregnancy and spontaneous delivery after total hypophysectomy. DESIGN: A case report. SETTING: University hospital. PATIENT(S): A 34-year-old woman with panhypopituitarism after hypophysectomy in childhood for craniopharyngioma. INTERVENTION(S): Successful fertility treatment followed by sufficient hormone substitution therapy during pregnancy. MAIN OUTCOME MEASURE(S): Clinical variables. RESULT(S): The patient had an uncomplicated spontaneous delivery without any substitution of oxytocin before, during, or after delivery. CONCLUSION(S): Normal pregnancy and delivery are possible in women with lack of pituitary function. Maternal pituitary oxytocin release seems to play a limited role in the onset and progression of labor.
OBJECTIVE: To report the first case of pregnancy and spontaneous delivery after total hypophysectomy. DESIGN: A case report. SETTING: University hospital. PATIENT(S): A 34-year-old woman with panhypopituitarism after hypophysectomy in childhood for craniopharyngioma. INTERVENTION(S): Successful fertility treatment followed by sufficient hormone substitution therapy during pregnancy. MAIN OUTCOME MEASURE(S): Clinical variables. RESULT(S): The patient had an uncomplicated spontaneous delivery without any substitution of oxytocin before, during, or after delivery. CONCLUSION(S): Normal pregnancy and delivery are possible in women with lack of pituitary function. Maternal pituitary oxytocin release seems to play a limited role in the onset and progression of labor.
Authors: Anna Aulinas; Nicole Stantonyonge; Apolonia García-Patterson; Juan M Adelantado; Carmen Medina; Juan José Espinós; Esther López; Susan M Webb; Rosa Corcoy Journal: Pituitary Date: 2021-11-30 Impact factor: 4.107